medRxiv, 2021
Mills MG, Bruce EA, Huang ML, Crothers JW, Hyrien O, Oura CAL, ...
RT-qPCR is used world-wide to test and trace the spread of SARS-CoV-2. Extraction-less or direct RT-PCR is an open-access qualitative method for SARS-CoV-2 detection from nasopharyngeal (NP) or oral pharyngeal (OP) samples with the potential to generate actionable data more quickly, at a lower cost, and with fewer experimental ...
Frontiers in Toxicology, 2021
Baron MG, Otter, RR, Connors KA, Kienzler A, & Embry MR
The ecological threshold of toxicological concern (ecoTTC) is analogous to traditional human health-based TTCs but with derivation and application to ecological species. An ecoTTC is computed from the probability distribution of predicted no effect concentrations (PNECs) derived from either chronic or extrapolated acute ...
Environmental and Molecular Mutagenesis, 2021
Dertinger SD, Bhalli JA, Roberts DJ, Stankowski LF, Gollapudi BB, ...
The rodent Pig‐a assay is a flow cytometric, phenotype‐based method used to measure in vivo somatic cell mutation. An Organization for Economic Co‐operation and Development (OECD) test guideline is currently being developed to support routine use of the assay for regulatory purposes (OECD project number ...
Global Epidemiology, 2021
Déglin SE, Chen CL, Miller DJ, Lewis RJ, Chang ET, Hamade AK, ...
Throughout history, environmental epidemiology has proven crucial to identify certain threats to human health and to provide a basis for the development of life-saving public health policies. However, epidemiologists are facing challenges when studying tenuous threats such as environmental exposure to chemicals, whose ...
Toxicological Sciences, 2020
Chorley BN, Ellinger-Ziegelbauer H, Tackett M, Simutis FJ, ...
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury in the loop of Henle and the collecting duct (CD). A cross-laboratory program to identify and characterize urinary microRNA (miRNA) patterns ...
Toxicological Sciences, 2020
Pettit SD
The COVID-19 pandemic has left many frightened, saddened, and angered at its impact on our lives and the world around us. The disease has laid bare failures to protect our citizens generally but our vulnerable and underserved most of all. Growing evidence reveals that minority and low-income populations are experiencing ...
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