Health and Environmental Sciences Institute
Health and Environmental Sciences Institute
Science of the Total Environment, 2019
Aude Kienzler, Stephanie Bopp, Marlies Halder, Michelle Embry, Andrew Worth
There is growing evidence that single substances present below their individual thresholds of effect may still contribute to combined effects. Here, the possible use of ecotoxicological threshold concentrations of no concern (i.e. 5th percentile of statistical distribution of ecotoxicological values) is investigated to fill data gaps in MRA.
Environmental Toxicology and Chemistry, 2019
Aude Kienzler, Kristin A. Connors, Mark Bonnell, Mace G. Barron, Amy Beasley, Cristina G. Inglis, Teresa J. Norberg‐King, Todd Martin, Hans Sanderson, Nathalie Vallotton, Peter Wilson, Michelle R. Embry
Multiple modes of action (MOA) frameworks have been developed in aquatic ecotoxicology, mainly based on fish toxicity. These frameworks provide information on a key determinant of chemical toxicity, but the MOA categories and level of specificity remain unique to each of the classification schemes. This study aimed to develop a consensus MOA assignment within EnviroTox (https://envirotoxdatabase.org/), a curated in vivo aquatic toxicity database, based on the following MOA classification schemes: Verhaar (modified) framework, ASTER, TEST, and OASIS.
Neuromethods, 2019
Zhen He, John Panos, James Raymick, Tetyana Konak, Li Cui, Diane B. Miller, James P. O’Callaghan, Serguei Liachenko, Merle G. Paule, Syed Z. Imam
A new method published as a book chapter for sampling cerebrospinal fluid in rat. (eds) Cell Culture Techniques. Neuromethods, vol 145. Humana, New York, NY
Toxicological Sciences, 2019
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, Ivan Kopljar, Karel van Ammel, Fetene Tekle, Ard Teisman, Jin Zhai, Holly Clouse, Jennifer Pierson, Michael Furniss, Armando Lagrutta, Frederick Sannajust, David J Gallacher
A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.
Cancer Treatment Reviews, 2019
George GC, Barata PC, Campbell A, Chen A, Cortes JE, Hyman DM, Jones L, Karagiannis T, Klaar S, Le-Rademacher JG, LoRusso P, Mandrekar SJ, Merino DM, Minasian LM, Mitchell SA, Montez S, O’Connor DJ, Pettit S, Silk E, Sloan JA, Stewart M, Takimoto CH, Wong GY, Yap TA, Cleeland CS, Hong DS
Attribution of adverse events (AEs) is critical to oncology drug development and the regulatory process. However, processes for determining the causality of AEs are often sub-optimal, unreliable, and inefficient. Thus, a toxicity-attribution workshop was conducted in Silver Spring, MD to develop guidance for improving attribution of AEs in oncology clinical trials.
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