Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing

Nature Reviews Drug Discovery, 2023

Francesco Marchetti, Renato Cardoso, Connie L. Chen, ...

The GTTC is pleased to share its newest publication, “Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing,” published in Nature Reviews Drug Discovery. The commentary highlights the potential applications, advantages and challenges associated with ...

Read more

Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review

Environmental and Molecular Mutagenesis, 2022

Douglas GR, Beevers C, Gollapudi B, Keig-Shevlin Z, Kirkland D, ...

This review was undertaken to assess whether the available data support the contention that there would be no substantial loss of mutations in rapidly proliferating tissues by increasing the sampling time from 3 to 28 days after the end of 28 days of dosing.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [suppress_filters] => 
            [ignore_sticky_posts] => 
            [cache_results] => 
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 26472
                    [post_author] => 16
                    [post_date] => 2023-03-07 13:32:39
                    [post_date_gmt] => 2023-03-07 13:32:39
                    [post_content] => 
                    [post_title] => New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => new-approach-methodologies-for-the-endocrine-activity-toolbox-environmental-assessment-for-fish-and-amphibians
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-03-07 13:32:39
                    [post_modified_gmt] => 2023-03-07 13:32:39
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26472
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 26519
                    [post_author] => 16
                    [post_date] => 2023-03-17 19:08:34
                    [post_date_gmt] => 2023-03-17 19:08:34
                    [post_content] => 
                    [post_title] => Current approaches to evaluate the function of cytotoxic T-cells in non-human primates
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => current-approaches-to-evaluate-the-function-of-cytotoxic-t-cells-in-non-human-primates
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-03-20 12:09:21
                    [post_modified_gmt] => 2023-03-20 12:09:21
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26519
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 26344
                    [post_author] => 16
                    [post_date] => 2023-01-17 13:05:06
                    [post_date_gmt] => 2023-01-17 13:05:06
                    [post_content] => 
                    [post_title] => Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => gttc-nature-reviews-drug-discovery-2023-01-16
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-01-17 13:08:03
                    [post_modified_gmt] => 2023-01-17 13:08:03
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26344
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 26318
                    [post_author] => 16
                    [post_date] => 2023-01-05 19:17:43
                    [post_date_gmt] => 2023-01-05 19:17:43
                    [post_content] => 
                    [post_title] => Quantitative in vitro to in vivo extrapolation of genotoxicity data provides protective estimates of in vivo dose
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => quantitative-in-vitro-to-in-vivo-extrapolation-of-genotoxicity-data-provides-protective-estimates-of-in-vivo-dose
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-01-05 19:17:43
                    [post_modified_gmt] => 2023-01-05 19:17:43
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26318
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 26319
                    [post_author] => 16
                    [post_date] => 2023-01-05 19:23:41
                    [post_date_gmt] => 2023-01-05 19:23:41
                    [post_content] => 
                    [post_title] => Establishing a Quantitative Framework for Regulatory Interpretation of Genetic Toxicity Dose-Response Data: MOE (Margin of Exposure) Case Study of 48 Compounds with both in vivo Mutagenicity and Carcinogenicity Dose-Response Data
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => establishing-a-quantitative-framework-for-regulatory-interpretation-of-genetic-toxicity-dose-response-data-moe-margin-of-exposure-case-study-of-48-compounds-with-both-in-vivo-mutagenicity-and-carci
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-01-17 13:24:01
                    [post_modified_gmt] => 2023-01-17 13:24:01
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26319
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 26152
                    [post_author] => 16
                    [post_date] => 2022-11-15 18:38:21
                    [post_date_gmt] => 2022-11-15 18:38:21
                    [post_content] => 
                    [post_title] => Impact of sampling time on the detection of mutations in rapidly proliferating tissues using transgenic rodent gene mutation models: A review
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => impact-of-sampling-time-on-the-detection-of-mutations-in-rapidly-proliferating-tissues-using-transgenic-rodent-gene-mutation-models-a-review
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-11-15 18:38:21
                    [post_modified_gmt] => 2022-11-15 18:38:21
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26152
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 26472
            [post_author] => 16
            [post_date] => 2023-03-07 13:32:39
            [post_date_gmt] => 2023-03-07 13:32:39
            [post_content] => 
            [post_title] => New Approach Methodologies for the Endocrine Activity Toolbox: Environmental Assessment for Fish and Amphibians
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => new-approach-methodologies-for-the-endocrine-activity-toolbox-environmental-assessment-for-fish-and-amphibians
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2023-03-07 13:32:39
            [post_modified_gmt] => 2023-03-07 13:32:39
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=26472
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 458
    [max_num_pages] => 77
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => da8332bd637111e1996ff6251563ba79
    [query_vars_changed:WP_Query:private] => 1
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.