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Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications

Drug Metabolism and Disposition, 2019

April Neal-Kluever, Jeffrey Fisher, Lawrence Grylack, Satoko Kakiuchi-Kiyota and Wendy Halpern

This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et al., 2018).

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Creation of a Curated Aquatic Toxicology Database: EnviroTox

Environmental Toxicology and Chemistry, 2019

Kristin A. Connors, Amy Beasley, Mace G. Barron, Scott E. Belanger, Mark Bonnell, Jessica L. Brill, Dick de Zwart, Aude Kienzler, Jesse Krailler, Ryan Otter, Joshua L. Phillips, Michelle R. Embry

The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

International Journal of Toxicology, 2018

Emmanuel Boulay, Matthew M. Abernathy, Ray Chu, Gregory S. Friedrichs, Nicolas Gendron-Parra, Andrea Greiter-Wilke, Jean-Michel Guillon, John E. Koerner, Ariane Menard, Jill Steidl-Nichols, Jennifer Pierson, Michael K. Pugsley, Eric I. Rossman, David Strauss, Eric Troncy, Jean-Pierre Valentin, Todd Wisialowski, Simon Authier

Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.

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Analyzing chemical substitution decisions among chemical and product manufacturers

Clean Technologies and Environmental Policy, 2018

Vikram M. Rao, Royce A. Francis, Jennifer Y. Tanir

The HESI Sustainable Alternatives Committee completed a study to understand potential tradeoffs concerning final product design and redesign decisions using a set of six factors affecting product design: business strategy, economic considerations, functionality and performance, health/environmental endpoints, public perception, and regulatory factors. The results are published here.

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