Peer-Reviewed Publications

All Publications

Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites

A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.

Read more

Improving Attribution of Adverse Events in Oncology Clinical Trials

Attribution of adverse events (AEs) is critical to oncology drug development and the regulatory process. However, processes for determining the causality of AEs are often sub-optimal, unreliable, and inefficient. Thus, a toxicity-attribution workshop was conducted in Silver Spring, MD to develop guidance for improving attribution of AEs in oncology clinical trials.

Read more

Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications

This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et al., 2018).

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 5
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => 
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [static] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
             => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_11_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_11_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_11_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_11_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_11_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_11_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => SELECT SQL_CALC_FOUND_ROWS  wp_11_posts.ID FROM wp_11_posts  INNER JOIN wp_11_postmeta ON ( wp_11_posts.ID = wp_11_postmeta.post_id ) WHERE 1=1  AND ( 
  wp_11_postmeta.meta_key = '_ilsi_date'
) AND wp_11_posts.post_type = 'publication' AND (wp_11_posts.post_status = 'publish') GROUP BY wp_11_posts.ID ORDER BY wp_11_postmeta.meta_value DESC LIMIT 0, 5
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 21153
                     => 13
                     => 2019-05-08 09:39:02
                    [post_date_gmt] => 2019-05-08 14:39:02
                    [post_content] => 
                    [post_title] => A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-method-for-sampling-rat-cerebrospinal-fluid-with-minimal-blood-contamination-a-critical-tool-for-biomarker-studies
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-05-08 09:39:02
                    [post_modified_gmt] => 2019-05-08 14:39:02
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=21153
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 21144
                     => 13
                     => 2019-05-07 09:41:43
                    [post_date_gmt] => 2019-05-07 14:41:43
                    [post_content] => 
                    [post_title] => Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => assessing-drug-induced-long-qt-and-proarrhythmic-risk-using-human-stem-cell-derived-cardiomyocytes-in-a-ca2-imaging-assay-evaluation-of-28-cipa-compounds-at-three-test-sites
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-05-07 09:43:44
                    [post_modified_gmt] => 2019-05-07 14:43:44
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=21144
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 21120
                     => 105
                     => 2019-05-03 09:50:46
                    [post_date_gmt] => 2019-05-03 14:50:46
                    [post_content] => 
                    [post_title] => Improving Attribution of Adverse Events in Oncology Clinical Trials
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => improving-attribution-of-adverse-events-in-oncology-clinical-trials
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-05-03 09:51:34
                    [post_modified_gmt] => 2019-05-03 14:51:34
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=21120
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 21017
                     => 105
                     => 2019-03-07 13:55:43
                    [post_date_gmt] => 2019-03-07 18:55:43
                    [post_content] => 
                    [post_title] => Ontogeny of ADME Processes During Postnatal Development in Man and Preclinical Species: A Comprehensive Review
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => ontogeny-of-adme-processes-during-postnatal-development-in-man-and-preclinical-species-a-comprehensive-review
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-03-07 13:55:43
                    [post_modified_gmt] => 2019-03-07 18:55:43
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=publication&p=21017
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 21018
                     => 105
                     => 2019-03-07 13:59:59
                    [post_date_gmt] => 2019-03-07 18:59:59
                    [post_content] => 
                    [post_title] => Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => physiology-of-the-neonatal-gastrointestinal-system-relevant-to-the-disposition-of-orally-administered-medications-2
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2019-03-07 14:50:43
                    [post_modified_gmt] => 2019-03-07 19:50:43
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://hesiglobal.org/?post_type=publication&p=21018
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 5
    [current_post] => -1
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 21153
             => 13
             => 2019-05-08 09:39:02
            [post_date_gmt] => 2019-05-08 14:39:02
            [post_content] => 
            [post_title] => A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => a-method-for-sampling-rat-cerebrospinal-fluid-with-minimal-blood-contamination-a-critical-tool-for-biomarker-studies
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2019-05-08 09:39:02
            [post_modified_gmt] => 2019-05-08 14:39:02
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=21153
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 381
    [max_num_pages] => 77
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 1927f7d2dbd55daef0655fe594864a08
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)