Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening
- Publication Date :
- Publication Type : Journal Article
- Author(s) : Brian Berridge, Jennifer Pierson, Syril Pettit, Norman Stockbridge
- Journal Name : Frontiers in Toxicology
This groundbreaking piece from the HESI Cardiac Safety Committee proposes a new alternative approach to preclinical drug safety assessment, using human cell-based models and computational methods to identify human-relevant liabilities earlier in the process.
Challenging the status quo: a framework for mechanistic and human-relevant cardiovascular safety screening. Berridge et al., March 2024. Frontiers in Toxicology. https://doi.org/10.3389/ftox.2024.1352783
