Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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A (not) new Rx: Quality Improvement for NAM

Regulatory Toxicology and Pharmacology, 2024

Syril D. Pettit

This Commentary asserts that the challenges of realizing the systems-level changes needed to catalyze the broad-scale adoption and use of New Approach Methodologies (NAMs) may be less unique than perceived to date, and points to specific opportunities to learn from decades of experience (both positive and negative) from the ...

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A 21st Century Roadmap for Human Health Risk Assessment

Critical Reviews in Toxicology, 2014

Pastoor TP, Bachman AN, Bell DR, Cohen SM, Dellarco M, ...
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government ...

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A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies

Toxicological Sciences, 2022

J. Christopher Corton, Constance A. Mitchell, Scott Auerbach, ...

This call-to-action paper published in Toxicological Sciences describes a multi-sector collaboration seeking to accelerate the evaluation of biomarker tools in carcinogenicity studies which will facilitate the transition from current heavy reliance on conventional 2-year rodent ...

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A comparative analysis of select P450 enzymes in uninduced and PB/BNF-induced hamster and rat liver S9

Mutation Research – Genetic Toxicology and Environmental Mutagenesis, 2025

Evans et al.

As part of its Nitrosamine Research Program (NRP), HESI’s Genetic Toxicology Technical Committee (GTTC) has supported the publication of a new study evaluating the relative CYP enzyme activities in uninduced and induced hamster and rat liver S9 preparations. This research is critical for assessing the metabolic ...

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A comparison of the lowest effective concentration in culture media for detection of chromosomal damage in vitro and in blood or plasma for detection of micronuclei in vivo

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2022

David Kirkland, James Whitwell, Robert Smith, ...

It is often assumed that genotoxic substances will be detected more easily by using in vitro rather than in vivo genotoxicity tests since higher concentrations, more cytotoxicity and static exposures can be achieved. However, there is a paucity of data demonstrating whether genotoxic substances are detected at lower ...

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