Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications

A (not) new Rx: Quality Improvement for NAM

This Commentary asserts that the challenges of realizing the systems-level changes needed to catalyze the broad-scale adoption and use of New Approach Methodologies (NAMs) may be less unique than perceived to date, and points to specific opportunities to learn from decades of experience (both positive and negative) from the ...

Read more

A 21st Century Roadmap for Human Health Risk Assessment

The Health and Environmental Sciences Institute (HESI)-coordinated Risk Assessment in the 21st Century (RISK21) project was initiated to develop a scientific, transparent, and efficient approach to the evolving world of human health risk assessment, and involved over 120 participants from 12 countries, 15 government ...

Read more

A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies

This call-to-action paper published in Toxicological Sciences describes a multi-sector collaboration seeking to accelerate the evaluation of biomarker tools in carcinogenicity studies which will facilitate the transition from current heavy reliance on conventional 2-year rodent ...

Read more

A comparative analysis of select P450 enzymes in uninduced and PB/BNF-induced hamster and rat liver S9

As part of its Nitrosamine Research Program (NRP), HESI’s Genetic Toxicology Technical Committee (GTTC) has supported the publication of a new study evaluating the relative CYP enzyme activities in uninduced and induced hamster and rat liver S9 preparations. This research is critical for assessing the metabolic ...

Read more

A comparison of the lowest effective concentration in culture media for detection of chromosomal damage in vitro and in blood or plasma for detection of micronuclei in vivo

It is often assumed that genotoxic substances will be detected more easily by using in vitro rather than in vivo genotoxicity tests since higher concentrations, more cytotoxicity and static exposures can be achieved. However, there is a paucity of data demonstrating whether genotoxic substances are detected at lower ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [orderby] => title
            [order] => ASC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 1
            [orderby] => title
            [order] => ASC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts 
					WHERE 1=1  AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					
					ORDER BY wp_posts.post_title ASC
					LIMIT 0, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 27734
                    [post_author] => 16
                    [post_date] => 2024-02-13 20:42:22
                    [post_date_gmt] => 2024-02-13 20:42:22
                    [post_content] => 
                    [post_title] => A (not) new Rx: Quality Improvement for NAM
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-not-new-rx-quality-improvement-for-nam
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2024-02-13 20:42:22
                    [post_modified_gmt] => 2024-02-13 20:42:22
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=27734
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 2617
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:20:31
                    [post_date_gmt] => 2016-05-05 01:20:31
                    [post_content] => 
                    [post_title] => A 21st Century Roadmap for Human Health Risk Assessment
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-21st-century-roadmap-for-human-health-risk-assessment
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:20:31
                    [post_modified_gmt] => 2016-05-05 01:20:31
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2617
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3262
                    [post_author] => 6
                    [post_date] => 2016-06-20 11:49:52
                    [post_date_gmt] => 2016-06-20 16:49:52
                    [post_content] => 
                    [post_title] => A Call for More Integrated Cardiovascular Safety Assessment
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-call-for-more-integrated-cardiovascular-safety-assessment
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 11:49:52
                    [post_modified_gmt] => 2016-06-20 16:49:52
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3262
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 25000
                    [post_author] => 16
                    [post_date] => 2022-07-05 16:19:13
                    [post_date_gmt] => 2022-07-05 16:19:13
                    [post_content] => 
                    [post_title] => A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-collaborative-initiative-to-establish-genomic-biomarkers-for-assessing-tumorigenic-potential-to-reduce-reliance-on-conventional-rodent-carcinogenicity-studies
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-07-05 16:19:42
                    [post_modified_gmt] => 2022-07-05 16:19:42
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=25000
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 29308
                    [post_author] => 16
                    [post_date] => 2025-03-03 15:34:09
                    [post_date_gmt] => 2025-03-03 15:34:09
                    [post_content] => 
                    [post_title] => A comparative analysis of select P450 enzymes in uninduced and PB/BNF-induced hamster and rat liver S9
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-comparative-analysis-of-select-p450-enzymes-in-uninduced-and-pb-bnf-induced-hamster-and-rat-liver-s9
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2025-03-03 15:34:09
                    [post_modified_gmt] => 2025-03-03 15:34:09
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=29308
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 25424
                    [post_author] => 16
                    [post_date] => 2022-06-22 16:00:03
                    [post_date_gmt] => 2022-06-22 16:00:03
                    [post_content] => 
                    [post_title] => A comparison of the lowest effective concentration in culture media for detection of chromosomal damage in vitro and in blood or plasma for detection of micronuclei in vivo
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => a-comparison-of-the-lowest-effective-concentration-in-culture-media-for-detection-of-chromosomal-damage-in-vitro-and-in-blood-or-plasma-for-detection-of-micronuclei-in-vivo
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-06-22 16:00:03
                    [post_modified_gmt] => 2022-06-22 16:00:03
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=25424
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 27734
            [post_author] => 16
            [post_date] => 2024-02-13 20:42:22
            [post_date_gmt] => 2024-02-13 20:42:22
            [post_content] => 
            [post_title] => A (not) new Rx: Quality Improvement for NAM
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => a-not-new-rx-quality-improvement-for-nam
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2024-02-13 20:42:22
            [post_modified_gmt] => 2024-02-13 20:42:22
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=27734
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 494
    [max_num_pages] => 83
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 0cc1255ed77f1aa1e5f715f017d589a2
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.