Frontiers in Pharmacology, 2019
Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, ...
- HESI - Health and Environmental Sciences Institute
Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects earlier in drug research using ...
Toxicologic Pathology, 2013
Reagan WJ, York M, Berridge B, Schultze E, Walker D, Pettit S
- HESI - Health and Environmental Sciences Institute
Cardiac troponin (cTn) has been utilized to assess acute myocardial injury, but the cTn response in active/ongoing chronic injury is not well documented.
International Journal of Toxicology, 2011
Sarazan RD, Mittelstadt S, Guth B, Koerner J, Zhang J, Pettit S
- HESI - Health and Environmental Sciences Institute
There are several recent examples where clinically significant, safety-related, drug effects on hemodynamics or cardiac function were not apparent until large clinical trials were completed or the drugs entered the consumer market.
Journal of Pharmacological and Toxicological Methods, 2017
E. Boulay, M.K. Pugsley, V. Jacquemet, A. Vinet, M.V. Accardi, ...
- HESI - Health and Environmental Sciences Institute
Heart rate correction methods are frequently used when analyzing data collected during the drug development process to better understand the QT interval. There is variability in this methodology and the optimal heart rate correction formula is often debated. This paper details a study that explored the ...
British Journal of Pharmacology, 2017
Park EJ, Gintant GA, Bi D, Kozeli D, Pettit SD, Pierson JB, ...
- HESI - Health and Environmental Sciences Institute
The strengths and limitations of three nonclinical repolarization assays used to define the risk of clinical drug-induced delayed ventricular repolarization (a surrogate marker of the rare but potentially lethal arrhythmia Torsades de Pointes) were compared during a retrospective analysis of an anonymized database of 150 ...
Toxicological Sciences, 2019
Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
- HESI - Health and Environmental Sciences Institute
A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.
WP_Query Object
(
[query] => Array
(
[post_type] => publication
[posts_per_page] => 6
[type] =>
[area] =>
[committee] => Cardiac Safety
[authors] => true
[showtitle] => false
[meta_query] => Array
(
[relation] => AND
)
[tax_query] => Array
(
[0] => Array
(
[taxonomy] => ilsi_committee
[field] => name
[terms] => Cardiac Safety
)
)
[paged] => 5
[orderby] => title
[order] => DESC
)
[query_vars] => Array
(
[post_type] => publication
[posts_per_page] => 6
[type] =>
[area] =>
[committee] => Cardiac Safety
[authors] => true
[showtitle] => false
[meta_query] => Array
(
[relation] => AND
)
[tax_query] => Array
(
[0] => Array
(
[taxonomy] => ilsi_committee
[field] => name
[terms] => Cardiac Safety
)
)
[paged] => 5
[orderby] => title
[order] => DESC
[error] =>
[m] =>
[p] => 0
[post_parent] =>
[subpost] =>
[subpost_id] =>
[attachment] =>
[attachment_id] => 0
[name] =>
[pagename] =>
[page_id] => 0
[second] =>
[minute] =>
[hour] =>
[day] => 0
[monthnum] => 0
[year] => 0
[w] => 0
[category_name] =>
[tag] =>
[cat] =>
[tag_id] =>
[author] =>
[author_name] =>
[feed] =>
[tb] =>
[meta_key] =>
[meta_value] =>
[preview] =>
[s] =>
[sentence] =>
[title] =>
[fields] =>
[menu_order] =>
[embed] =>
[category__in] => Array
(
)
[category__not_in] => Array
(
)
[category__and] => Array
(
)
[post__in] => Array
(
)
[post__not_in] => Array
(
)
[post_name__in] => Array
(
)
[tag__in] => Array
(
)
[tag__not_in] => Array
(
)
[tag__and] => Array
(
)
[tag_slug__in] => Array
(
)
[tag_slug__and] => Array
(
)
[post_parent__in] => Array
(
)
[post_parent__not_in] => Array
(
)
[author__in] => Array
(
)
[author__not_in] => Array
(
)
[suppress_filters] =>
[ignore_sticky_posts] =>
[cache_results] =>
[update_post_term_cache] => 1
[lazy_load_term_meta] => 1
[update_post_meta_cache] => 1
[nopaging] =>
[comments_per_page] => 50
[no_found_rows] =>
[taxonomy] => ilsi_committee
[term_id] => Cardiac Safety
)
[tax_query] => WP_Tax_Query Object
(
[queries] => Array
(
[0] => Array
(
[taxonomy] => ilsi_committee
[terms] => Array
(
[0] => Cardiac Safety
)
[field] => name
[operator] => IN
[include_children] => 1
)
)
[relation] => AND
[table_aliases:protected] => Array
(
[0] => wp_term_relationships
)
[queried_terms] => Array
(
[ilsi_committee] => Array
(
[terms] => Array
(
[0] => Cardiac Safety
)
[field] => name
)
)
[primary_table] => wp_posts
[primary_id_column] => ID
)
[meta_query] => WP_Meta_Query Object
(
[queries] => Array
(
)
[relation] => AND
[meta_table] =>
[meta_id_column] =>
[primary_table] =>
[primary_id_column] =>
[table_aliases:protected] => Array
(
)
[clauses:protected] => Array
(
)
[has_or_relation:protected] =>
)
[date_query] =>
[request] =>
SELECT SQL_CALC_FOUND_ROWS wp_posts.ID
FROM wp_posts LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id)
WHERE 1=1 AND (
wp_term_relationships.term_taxonomy_id IN (17)
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
GROUP BY wp_posts.ID
ORDER BY wp_posts.post_title DESC
LIMIT 24, 6
[posts] => Array
(
[0] => WP_Post Object
(
[ID] => 22513
[post_author] => 2
[post_date] => 2020-03-25 07:46:39
[post_date_gmt] => 2020-03-25 12:46:39
[post_content] =>
[post_title] => Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => considerations-for-an-in-vitro-cell-based-testing-platform-for-detection-of-adverse-drug-induced-inotropic-effects-in-early-drug-development-part-1-general-considerations-for-development-of-novel-t
[to_ping] =>
[pinged] =>
[post_modified] => 2020-03-25 07:46:39
[post_modified_gmt] => 2020-03-25 12:46:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22513
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[1] => WP_Post Object
(
[ID] => 2687
[post_author] => 6
[post_date] => 2016-05-10 09:52:14
[post_date_gmt] => 2016-05-10 14:52:14
[post_content] =>
[post_title] => Comparison of Cardiac Troponin I and T, Including the Evaluation of an Ultrasensitive Assay, as Indicators of Doxorubicin-Induced Cardiotoxicity
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => comparison-of-cardiac-troponin-i-and-t-including-the-evaluation-of-an-ultrasensitive-assay-as-indicators-of-doxorubicin-induced-cardiotoxicity
[to_ping] =>
[pinged] =>
[post_modified] => 2016-05-10 09:52:14
[post_modified_gmt] => 2016-05-10 14:52:14
[post_content_filtered] =>
[post_parent] => 0
[guid] => http://ilsi.org/hesi/?post_type=publication&p=2687
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[2] => WP_Post Object
(
[ID] => 3241
[post_author] => 6
[post_date] => 2016-06-18 00:17:17
[post_date_gmt] => 2016-06-18 05:17:17
[post_content] =>
[post_title] => Cardiovascular Function in Nonclinical Drug Safety Assessment Current Issues and Opportunities
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => cardiovascular-function-in-nonclinical-drug-safety-assessment-current-issues-and-opportunities
[to_ping] =>
[pinged] =>
[post_modified] => 2016-06-18 00:17:17
[post_modified_gmt] => 2016-06-18 05:17:17
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=3241
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[3] => WP_Post Object
(
[ID] => 4949
[post_author] => 8
[post_date] => 2017-09-11 13:15:44
[post_date_gmt] => 2017-09-11 18:15:44
[post_content] =>
[post_title] => Cardiac contractility: Correction strategies applied to telemetry data from a HESI-sponsored consortium
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => cardiac-contractility-correction-strategies-applied-to-telemetry-data-from-a-hesi-sponsored-consortium
[to_ping] =>
[pinged] =>
[post_modified] => 2017-09-11 13:15:44
[post_modified_gmt] => 2017-09-11 18:15:44
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=4949
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[4] => WP_Post Object
(
[ID] => 6550
[post_author] => 8
[post_date] => 2017-12-15 11:04:39
[post_date_gmt] => 2017-12-15 16:04:39
[post_content] =>
[post_title] => Can Nonclinical Repolarization Assays Predict the Results of Clinical Thorough QT Studies? Results from a Research Consortium.
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => can-nonclinical-repolarization-assays-predict-the-results-of-clinical-thorough-qt-studies-results-from-a-research-consortium
[to_ping] =>
[pinged] =>
[post_modified] => 2017-12-15 11:04:39
[post_modified_gmt] => 2017-12-15 16:04:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=6550
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[5] => WP_Post Object
(
[ID] => 21144
[post_author] => 8
[post_date] => 2019-05-07 09:41:43
[post_date_gmt] => 2019-05-07 14:41:43
[post_content] =>
[post_title] => Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => assessing-drug-induced-long-qt-and-proarrhythmic-risk-using-human-stem-cell-derived-cardiomyocytes-in-a-ca2-imaging-assay-evaluation-of-28-cipa-compounds-at-three-test-sites
[to_ping] =>
[pinged] =>
[post_modified] => 2019-05-07 09:41:43
[post_modified_gmt] => 2019-05-07 14:41:43
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=21144
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
)
[post_count] => 6
[current_post] => -1
[in_the_loop] =>
[post] => WP_Post Object
(
[ID] => 22513
[post_author] => 2
[post_date] => 2020-03-25 07:46:39
[post_date_gmt] => 2020-03-25 12:46:39
[post_content] =>
[post_title] => Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => considerations-for-an-in-vitro-cell-based-testing-platform-for-detection-of-adverse-drug-induced-inotropic-effects-in-early-drug-development-part-1-general-considerations-for-development-of-novel-t
[to_ping] =>
[pinged] =>
[post_modified] => 2020-03-25 07:46:39
[post_modified_gmt] => 2020-03-25 12:46:39
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22513
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[comment_count] => 0
[current_comment] => -1
[found_posts] => 36
[max_num_pages] => 6
[max_num_comment_pages] => 0
[is_single] =>
[is_preview] =>
[is_page] =>
[is_archive] => 1
[is_date] =>
[is_year] =>
[is_month] =>
[is_day] =>
[is_time] =>
[is_author] =>
[is_category] =>
[is_tag] =>
[is_tax] => 1
[is_search] =>
[is_feed] =>
[is_comment_feed] =>
[is_trackback] =>
[is_home] =>
[is_privacy_policy] =>
[is_404] =>
[is_embed] =>
[is_paged] => 1
[is_admin] =>
[is_attachment] =>
[is_singular] =>
[is_robots] =>
[is_favicon] =>
[is_posts_page] =>
[is_post_type_archive] =>
[query_vars_hash:WP_Query:private] => c134d3f76f44b0e487b7abe5435f32f2
[query_vars_changed:WP_Query:private] => 1
[thumbnails_cached] =>
[allow_query_attachment_by_filename:protected] =>
[stopwords:WP_Query:private] =>
[compat_fields:WP_Query:private] => Array
(
[0] => query_vars_hash
[1] => query_vars_changed
)
[compat_methods:WP_Query:private] => Array
(
[0] => init_query_flags
[1] => parse_tax_query
)
)