HESI Cardiac Safety Early Career Webinar Series – Shagun Krishna

The Cardiac Safety Steering Team is proud to present the final webinar featuring Early Career Seminar Series Awardees.  This competitive award is given to postdoctoral or early career scientists who have compelling research related to cardiovascular safety and risk assessment.

Three awardees were selected for this inaugural Seminar Series:

• Dr. Julia Hotek, Merck (11 February, 2022)
• Dr. Arvin Soepriatna, Brown University (8 April, 2022)
• Dr. Shagun Krishna, NTP-NIEHS (12 May, 2022)

Please join us for our final webinar on May 12th at 10:00 am ET where Dr. Shagun Krishna will present her talk titled "Computational Cardiotoxicology: Building an AI-assisted pipeline".

Bio: Shagun Krishna, PhD is working at the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), National Toxicology Program (NTP). She received her PhD degree in Bioinformatics from CSIR-Central Drug Research Institute, India. With expertise in cheminformatics, molecular modeling, big data and artificial intelligence, her research at NTP involves development of a pipeline for cardiovascular risk assessment of several pharmaceutical and environmental chemicals. She has led a project to interpret Tox21/ToxCast high-throughput screening (HTS), map the HTS assay targets to biological pathways that represent key failure modes in cardiovascular disease, and use the observed patterns of bioactivity to screen and rank over 1,000 chemicals for their potential cardiotoxicity. Her current research applies cheminformatics, artificial intelligence, and machine learning in a variety of ways, including building structure activity relationship models and developing evidence maps of the literature supporting environmental contributions to cardiovascular effects. She is also investigating the health risk of these chemicals by applying in vitro-to-in vivo extrapolation (IVIVE) approaches for converting the bioactivity values derived from in vitro testing to an equivalent external exposure, to allow direct comparison between chemical hazard levels and anticipated exposure scenarios. Shagun has received numerous award and recognitions for her research including the Yves Alarie Scholarship Fund and the Dharm V. Singh Association of Scientists of Indian Origin Student Award Fund by Society of Toxicology (SOT). Her long-term goals are to establish a standardized pipeline to reduce animal testing in CV risk assessment by utilizing cutting edge alternative methods.

Registration is free, contact for details: HESI Cardiac Safety cardiacsafety@hesiglobal.org