Translational Biomarkers of Neurotoxicity (NeuTox) Committee

Mission Statement

The committee’s mission is to identify biomarkers for improving the prediction of neurotoxicity and seizurogenic compounds using microelectrode array (MEA).

Working Groups

  • Translational Biomarkers of Neurotoxicity

    This group is working toward identifying biomarkers of improving the prediction of neurotoxicity and identifying correlations in behavioral, imaging, and neuropathological endpoints. A phase 2
    study was launched to validate a set of biomarkers of neurotoxicity.

  • Microelectrode Array Subteam

    This group is working toward characterizing the predictivity of seizurogenic activity using MEA technology. A final analysis of data generated from a multi-site study is expected by early 2023.

  • Think Tank Planning Subteam

    A subteam was formed to plan a small Think Tank workshop where participants will
    discuss possible new areas of focus and next steps.

HESI Staff

Leadership Team

  • Tucker Patterson, PhD

    U.S. Food & Drug Administration

  • Ruth Roberts, PhD, FRSB, FRCPath

    ApconiX, Ltd.

Committee Publications

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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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Can We Panelize Seizure?

Toxicological Sciences, 2020

Roberts R, Authier S, Mellon D, Morton M, Suzuki I, Tjalkens RB, ...

Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs ...

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Changes in the Metabolome and microRNA Levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study

Experimental Biology and Medicine, 2017

Imam SZ, He Z, Cuevas E, Rosas-Hernandez H, Lantz SM, Sarkar S, ...

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at ...

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Drug Discovery and Development: Biomarkers of Neurotoxicity and Neurodegeneration

Experimental Biology and Medicine, 2018

Walker AL, Imam SZ, & Roberts RA

Attrition in drug discovery and development remains a major challenge. Safety/toxicity is the most prevalent reason for failure with cardiovascular and CNS toxicities predominating. Non-invasive biomarkers of neurotoxicity would provide significant advantage by allowing earlier prediction of likely neurotoxicity in ...

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Translational Biomarkers of Neurotoxicity: A Health and Environmental Sciences Institute Perspective on the Way Forward

Toxicological Sciences, 2015

Roberts RA, Aschner M, Calligaro D, Guilarte TR, Hanig JP, ...

Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking. There is a need for more sensitive and specific biomarkers of neurotoxicity that can help diagnose and predict neurotoxicity that are relevant across animal models and translational from ...

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Events

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Society for Neuroscience Annual Meeting

October 8, 2024

Chicago, IL, USA

We are excited to announce the upcoming Translational Biomarkers of Neurotoxicity (NeuTox) Mini Session at this year's Society for Neuroscience Annual Meeting in Chicago!

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Society of Toxicology Meeting 2023

March 19, 2023 – March 23, 2023

Nashville, TN, USA

A number of HESI committees will have presentations and posters at the Society of Toxicology Meeting in Nashville, TN.

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HESI at ICT2022 Symposium

September 18, 2022 – September 21, 2022

Maastricht, The Netherlands

HESI will be attending the International Congress of Toxicology in Maastricht, Netherlands from 18-21 September 2022.

Read more

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Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403

740 15th Street NW, Suite 600
Washington, DC 20005

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