A new method published as a book chapter for sampling cerebrospinal fluid in rat. (eds) Cell Culture Techniques. Neuromethods, vol 145. Humana, New York, NY
Translational Biomarkers of Neurotoxicity Committee
Translational Biomarkers of Neurotoxicity (NeuTox) Committee
To identify biomarkers for improving the prediction of neurotoxicity.
William Slikker, PhD
US Food and Drug Administration
Ruth Roberts, PhD
University of Birmingham
Members and Fact Sheet
Impact Statement: Attrition in drug discovery and development remains a major challenge. Safety/toxicity is the most prevalent reason for failure with cardiovascular and CNS toxicities predominating. Non-invasive biomarkers of neurotoxicity would provide significant advantage by allowing earlier prediction of likely neurotoxicity in preclinical studies as well as facilitating clinical trials of new therapies for neurodegenerative conditions such as Parkinson’s disease (PD) and multiple sclerosis (MS).
The HESI Translational Biomarkers of Neurotoxicity Committee conducted a pilot study to identify noninvasive, fluidic biomarkers of neurotoxicity.
Neurotoxicity has been linked to a number of common drugs and chemicals, yet efficient and accurate methods to detect it are lacking.