Translational Biomarkers of Neurotoxicity (NeuTox) Committee

 

Translational Biomarkers of Neurotoxicity (NeuTox) Committee

Mission Statement

To identify biomarkers for improving the prediction of neurotoxicity.

 

Committee Contacts

HESI Staff

Jennifer Pierson
jpierson@hesiglobal.org

Leadership Team

William Slikker, PhD
US Food and Drug Administration

Ruth Roberts, PhD
University of Birmingham

Members and Fact Sheet

Committee Publications

All Publications

Drug discovery and development: Biomarkers of neurotoxicity and neurodegeneration.

Impact Statement: Attrition in drug discovery and development remains a major challenge. Safety/toxicity is the most prevalent reason for failure with cardiovascular and CNS toxicities predominating. Non-invasive biomarkers of neurotoxicity would provide significant advantage by allowing earlier prediction of likely neurotoxicity in preclinical studies as well as facilitating clinical trials of new therapies for neurodegenerative conditions such as Parkinson’s disease (PD) and multiple sclerosis (MS).

Read more

Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study.

The HESI Translational Biomarkers of Neurotoxicity Committee conducted a pilot study to identify noninvasive, fluidic biomarkers of neurotoxicity.

Read more

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