Journal of Pharmacological and Toxicological Methods, 2009
Trepakova ES, Koerner J, Pettit SD, Valentin JP
Drug-induced ventricular arrhythmia and Torsades de Pointes remain a serious public health issues in bringing safe new pharmaceuticals to the market place.
Clinical Chemistry, 2008
Apple FS, Murakami MM, Ler R, Walker D, York M, ...
Information is needed regarding analytical characteristics of cardiac troponin (cTn) assays used in preclinical studies.
British Journal of Pharmacology, 2008
Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, ...
Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients.
British Journal of Pharmacology, 2008
Bass AS, Darpo B, Valentin JP, Sager P, Thomas K
Drug-induced torsades de pointes (TdP) remains a significant public health concern that has challenged scientists who have the responsibility of advancing new medicines through development to the patient, while assuring public safety.
Journal of Pharmacological and Toxicological Methods, 2006
Hanson LA, Bass AS, Gintant G, Mittelstadt S, Rampe D, Thomas K
Drugs that delay cardiac repolarization pose potential safety risks to patients and cause serious regulatory concern because of the link between QT interval prolongation and the potentially fatal arrhythmia torsades de pointes (TdP).
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