The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens.
Characterization and Interlaboratory Comparison of a Gene Expression Signature for Differentiating Genotoxic Mechanisms
Toxicological Sciences, 2009
Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.
Toxicological Sciences, 2009
The genotoxicity testing battery is highly sensitive for detection of chemical carcinogens.
Experimental Biology and Medicine, 2017
Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at ...
Frontiers in Toxicology, 2024
This groundbreaking piece from the HESI Cardiac Safety Committee proposes a new alternative approach to preclinical drug safety assessment, using human cell-based models and computational methods to identify human-relevant liabilities earlier in the process.
Advanced Drug Delivery Reviews, 2014
Alveolar macrophage (AM) responses are commonly induced in inhalation toxicology studies, typically being observed as an increase in number or a vacuolated ‘foamy’ morphology.
International Journal of Toxicology, 2011
There are several recent examples where clinically significant, safety-related, drug effects on hemodynamics or cardiac function were not apparent until large clinical trials were completed or the drugs entered the consumer market.
Journal of Pharmacological and Toxicological Methods, 2017
Heart rate correction methods are frequently used when analyzing data collected during the drug development process to better understand the QT interval. There is variability in this methodology and the optimal heart rate correction formula is often debated. This paper details a study that explored the ...
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