Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Utilization of Juvenile Animal Studies to Determine the Human Effects and Risks of Environmental Toxicants During Postnatal Developmental Stages

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2004

Brent RL
  • HESI - Health and Environmental Sciences Institute

Toxicology studies utilizing animals and in vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures.

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 68
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 68
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [suppress_filters] => 
            [ignore_sticky_posts] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 402, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 3430
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:47:08
                    [post_date_gmt] => 2016-06-27 21:47:08
                    [post_content] => 
                    [post_title] => Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => identification-of-platform-independent-gene-expression-markers-of-cisplatin-nephrotoxicity
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:47:08
                    [post_modified_gmt] => 2016-06-27 21:47:08
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3430
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 3431
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:48:21
                    [post_date_gmt] => 2016-06-27 21:48:21
                    [post_content] => 
                    [post_title] => Overview of an Interlaboratory Collaboration on Evaluating the Effects of Model Hepatotoxicants on Hepatic Gene Expression
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => overview-of-an-interlaboratory-collaboration-on-evaluating-the-effects-of-model-hepatotoxicants-on-hepatic-gene-expression
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:48:21
                    [post_modified_gmt] => 2016-06-27 21:48:21
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3431
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3432
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:48:36
                    [post_date_gmt] => 2016-06-27 21:48:36
                    [post_content] => 
                    [post_title] => Interlaboratory Evaluation of Rat Hepatic Gene Expression Changes Induced by Methapyrilene
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => interlaboratory-evaluation-of-rat-hepatic-gene-expression-changes-induced-by-methapyrilene
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:48:36
                    [post_modified_gmt] => 2016-06-27 21:48:36
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3432
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 3407
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:50:50
                    [post_date_gmt] => 2016-06-27 21:50:50
                    [post_content] => 
                    [post_title] => Utilization of Juvenile Animal Studies to Determine the Human Effects and Risks of Environmental Toxicants During Postnatal Developmental Stages
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => utilization-of-juvenile-animal-studies-to-determine-the-human-effects-and-risks-of-environmental-toxicants-during-postnatal-developmental-stages
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:50:50
                    [post_modified_gmt] => 2016-06-27 21:50:50
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3407
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 3408
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:51:29
                    [post_date_gmt] => 2016-06-27 21:51:29
                    [post_content] => 
                    [post_title] => The Effects of Feed Restriction During In Utero and Postnatal Development in Rats
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => the-effects-of-feed-restriction-during-in-utero-and-postnatal-development-in-rats
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:51:29
                    [post_modified_gmt] => 2016-06-27 21:51:29
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3408
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 3415
                    [post_author] => 6
                    [post_date] => 2016-06-27 16:52:25
                    [post_date_gmt] => 2016-06-27 21:52:25
                    [post_content] => 
                    [post_title] => Juvenile Animal Studies: Testing Strategies and Design
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => juvenile-animal-studies-testing-strategies-and-design
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-27 16:52:25
                    [post_modified_gmt] => 2016-06-27 21:52:25
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3415
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 3430
            [post_author] => 6
            [post_date] => 2016-06-27 16:47:08
            [post_date_gmt] => 2016-06-27 21:47:08
            [post_content] => 
            [post_title] => Identification of Platform-Independent Gene Expression Markers of Cisplatin Nephrotoxicity
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => identification-of-platform-independent-gene-expression-markers-of-cisplatin-nephrotoxicity
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-06-27 16:47:08
            [post_modified_gmt] => 2016-06-27 21:47:08
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=3430
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 472
    [max_num_pages] => 79
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 7dbb6617673aae5735ec42b0528cb435
    [query_vars_changed:WP_Query:private] => 1
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.