Guest Editorial: Toxicogenomics in Risk Assessment: Communicating the Challenges

Environmental Health Perspectives. 2004;112(12):A662

In 1999 the membership of the International Life Sciences Institute (ILSI) Health and Environmental Sciences Institute (HESI) formed a multisector consortium to address challenges associated with the integration of genomics data into risk assessment (Pennie et al. 2004). Following its formation, the HESI Committee on the Application of Genomics to Mechanism-Based Risk Assessment identified several key hurdles. These included a lack of publicly available toxicogenomics databases, a lack of validation of available technologies, questions concerning the comparability of different technical platforms and how transcription products relate to toxicity, and uncertain regulatory applications.

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