Collaboration on Ototoxicity Risk Assessment (CORA)

Mission Statement

The collaborative mission of the committee is to better understand the impacts on the inner ear, resulting from co-exposures to noise and known and suspected ototoxic substances, in the pursuit of identifying safe exposure levels which minimize or eliminate the risk of ototoxicity to the consumer or worker.

Working Groups

  • Collaboration on Ototoxicity Risk Assessment (CORA)

    CORA was officially convened in March 2021 as the newest HESI Emerging Issues 2019-20 Call for Proposals, HESI’s traditional new project adoption process. CORA’s initial focus is on identifying gaps through a contemporary targeted review of the literature. Through the literature search, the committee aims to understand and identify gaps in hazard assessment of co-exposure to noise and chemical solvents. The results will be published in a manuscript.

  • Toxicology Study Sub-group

    The subgroup is conducting an animal toxicology study exploring co-exposure to noise and an ototoxic chemical in rodents.

  • Manuscript Development Sub-group

    This subgroup focuses on the writing, figure development, and designation of tasks to advance the publication of the literature scoping review.

HESI Staff

Leadership Team

  • Adrian Fuente, PhD

    University of Montreal

  • Laura Maurer, MPH, PhD

    ExxonMobil Biomedical Sciences, Inc.

Project Plan

Year 1: Problem Formulation & Scoping – Hazard & Exposure Assessment
Project 1: Begin to systematically understand and clarify data gaps in hazard assessment
Project 2: Provide the necessary perspective for use of large biometric databases

Year 2: Publications of Project 1 & Project 2
Project 3: Assessment of current, historically-utilized clinical metrics for ototoxicity against new, improved methods

Year 3: Storyboarding of Project 3 for Publication
Project 4: Development and initiation of fit-for-purpose animal studies to address the most significant data gaps identified in Project 1

To view the full project proposal, please click here.

Committee Events

Filter

36th World Congress of Audiology

Paris, France

HESI CORA members presented preliminary results of the literature review at the 2024 World Congress of Audiology in Paris, France.

Read more

CORA Presentation at API

virtual, CORA

Raechel Puglisi, MPH, will be presenting on behalf of the HESI Collaboration on Ototoxicity Risk Assessment (CORA) to the American Petroleum Institute (API) on 16 November 2021. She will be presenting on the current state of the science regarding ototoxicity, CORA’s current program ...

Read more

Collaboration on Ototoxicity Risk Assessment (CORA): Understanding Ototoxicity Risk

virtual, hosted by HESI

Collaboration on Ototoxicity Risk Assessment (CORA): Understanding Ototoxicity Risk by Dr. Rick Neitzel, University of Michigan. HESI’s newest project from the Emerging Issues Committee is the Collaboration on Ototoxicity Risk Assessment (CORA). CORA is focused on finding a better understanding of the causes and risks of ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => event
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [before] => 2050-01-01
            [after] => 
            [tags] => CORA
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => CORA
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => event
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [before] => 2050-01-01
            [after] => 
            [tags] => CORA
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                    [0] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                    [1] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                        )

                )

            [paged] => 1
            [tax_query] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [field] => name
                            [terms] => CORA
                        )

                )

            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 833
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [taxonomy] => post_tag
                            [terms] => Array
                                (
                                    [0] => CORA
                                )

                            [field] => name
                            [operator] => IN
                            [include_children] => 1
                        )

                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                    [0] => wp_term_relationships
                )

            [queried_terms] => Array
                (
                    [post_tag] => Array
                        (
                            [terms] => Array
                                (
                                    [0] => CORA
                                )

                            [field] => name
                        )

                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [1] => Array
                        (
                            [0] => Array
                                (
                                    [key] => _ilsi_date
                                    [value] => 2050-01-01
                                    [compare] => <=
                                )

                            [1] => Array
                                (
                                    [key] => _ilsi_end_date
                                    [value] => 2050-01-01
                                    [compare] => <=
                                )

                            [relation] => AND
                        )

                    [relation] => AND
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                    [1] => mt1
                    [2] => mt2
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                    [mt1] => Array
                        (
                            [key] => _ilsi_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt1
                            [cast] => CHAR
                        )

                    [mt2] => Array
                        (
                            [key] => _ilsi_end_date
                            [value] => 2050-01-01
                            [compare] => <=
                            [compare_key] => =
                            [alias] => mt2
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id) INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )  INNER JOIN wp_postmeta AS mt1 ON ( wp_posts.ID = mt1.post_id )  INNER JOIN wp_postmeta AS mt2 ON ( wp_posts.ID = mt2.post_id )
					WHERE 1=1  AND ( 
  wp_term_relationships.term_taxonomy_id IN (833)
) AND ( 
  wp_postmeta.meta_key = '_ilsi_date' 
  AND 
  ( 
    ( mt1.meta_key = '_ilsi_date' AND mt1.meta_value <= '2050-01-01' ) 
    AND 
    ( mt2.meta_key = '_ilsi_end_date' AND mt2.meta_value <= '2050-01-01' )
  )
) AND ((wp_posts.post_type = 'event' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 0, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 28833
                    [post_author] => 16
                    [post_date] => 2024-11-05 13:56:54
                    [post_date_gmt] => 2024-11-05 13:56:54
                    [post_content] => 
                    [post_title] => 36th  World Congress of Audiology
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => 36th-world-congress-of-audiology
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2024-11-05 13:56:54
                    [post_modified_gmt] => 2024-11-05 13:56:54
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=28833
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 26413
                    [post_author] => 16
                    [post_date] => 2023-02-09 13:44:47
                    [post_date_gmt] => 2023-02-09 13:44:47
                    [post_content] => 
                    [post_title] => HESI CORA Spring Meeting
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => hesi-cora-spring-meeting
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-02-09 13:44:47
                    [post_modified_gmt] => 2023-02-09 13:44:47
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=26413
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 24726
                    [post_author] => 16
                    [post_date] => 2022-03-10 16:00:46
                    [post_date_gmt] => 2022-03-10 16:00:46
                    [post_content] => 
                    [post_title] => CORA Presentation at API
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cora-presentation-at-api
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-03-10 16:00:46
                    [post_modified_gmt] => 2022-03-10 16:00:46
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=24726
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 24720
                    [post_author] => 16
                    [post_date] => 2022-03-10 15:47:03
                    [post_date_gmt] => 2022-03-10 15:47:03
                    [post_content] => 
                    [post_title] => Collaboration on Ototoxicity Risk Assessment (CORA): Understanding Ototoxicity Risk
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => collaboration-on-ototoxicity-risk-assessment-cora-understanding-ototoxicity-risk
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-03-10 15:47:03
                    [post_modified_gmt] => 2022-03-10 15:47:03
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=event&p=24720
                    [menu_order] => 0
                    [post_type] => event
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 4
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 28833
            [post_author] => 16
            [post_date] => 2024-11-05 13:56:54
            [post_date_gmt] => 2024-11-05 13:56:54
            [post_content] => 
            [post_title] => 36th  World Congress of Audiology
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => 36th-world-congress-of-audiology
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2024-11-05 13:56:54
            [post_modified_gmt] => 2024-11-05 13:56:54
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=event&p=28833
            [menu_order] => 0
            [post_type] => event
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 4
    [max_num_pages] => 1
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 1
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 1
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => ead41bae4fa56fe1351fe9261636e3e1
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-8403

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.