Collaboration on Ototoxicity Risk Assessment (CORA)

Mission Statement

The collaborative mission of the committee is to better understand the impacts on the inner ear, resulting from co-exposures to noise and known and suspected ototoxic substances, in the pursuit of identifying safe exposure levels which minimize or eliminate the risk of ototoxicity to the consumer or worker.

Working Groups

  • Collaboration on Ototoxicity Risk Assessment (CORA)

    CORA was officially convened in March 2021 as the newest HESI Emerging Issues 2019-20 Call for Proposals, HESI’s traditional new project adoption process. CORA’s initial focus is on identifying gaps through a contemporary targeted review of the literature. Through the literature search, the committee aims to understand and identify gaps in hazard assessment of co-exposure to noise and chemical solvents. The results will be published in a manuscript.

  • Toxicology Study Sub-group

    The subgroup is conducting an animal toxicology study exploring co-exposure to noise and an ototoxic chemical in rodents.

  • Manuscript Development Sub-group

    This subgroup focuses on the writing, figure development, and designation of tasks to advance the publication of the literature scoping review.

HESI Staff

Leadership Team

  • Adrian Fuente, PhD

    University of Montreal

  • Laura Maurer, MPH, PhD

    ExxonMobil Biomedical Sciences, Inc.

Project Plan

Year 1: Problem Formulation & Scoping – Hazard & Exposure Assessment
Project 1: Begin to systematically understand and clarify data gaps in hazard assessment
Project 2: Provide the necessary perspective for use of large biometric databases

Year 2: Publications of Project 1 & Project 2
Project 3: Assessment of current, historically-utilized clinical metrics for ototoxicity against new, improved methods

Year 3: Storyboarding of Project 3 for Publication
Project 4: Development and initiation of fit-for-purpose animal studies to address the most significant data gaps identified in Project 1

To view the full project proposal, please click here.

Committee Events

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