February 11, 2021
Webinar, hosted by HESI and the American Association of Pharmaceutical Scientists (AAPS)
Noninvasive monitoring of nephrotoxicity is challenging. Kidney toxicity is currently monitored by plasma/serum markers, e.g., blood urea nitrogen, and serum creatinine, and urinary markers, such as urinary volume, specific gravity, or osmolality, protein, fractional electrolyte excretion, or sediment examination). ...
January 11, 2021 – January 12, 2021
Virtual meeting, hosted by HESI Board of Trustees
The HESI Board of Trustees will meet to review 2020 achievements and challenges, approve a 2021 organizational budget, progress the strategic plan, and refine Board priorities for 2021. This is a closed meeting for HESI staff and the HESI Board of Trustees.
December 3, 2020
Virtual workshop, hosted by HESI and the Environmental Mutagenesis and Genomics Society (EMGS)
The workshop will (1) provide a brief overview of the state of the science regarding quantitative interpretation of genetic toxicity dose-response data, including a brief overview of the BMD combined covariate approach for potency ranking and MOA investigation, (2) a summary of recent genotoxicity risk assessment case ...
October 21, 2020 – October 22, 2020
Virtual workshop, hosted by the HESI PATB Committee
The HESI Protein Allergens, Toxins, and Bioinformatics (PATB) Committee is hosting a virtual workshop focusing on the state of the science for a wide array of protein toxins classes, MOAs, structures, activity, and general biology. Additionally, the workshop will cover the bioinformatics analysis of protein toxins and how ...
October 17, 2020 – December 31, 2020
Online submission, via HESI THRIVE
HESI THRIVE is a seed grant program that is innovating translational research and improving quality of life after cancer. By providing researchers with both seed funding and access to critical networks, THRIVE enhances the visibility of the patient need, the value of the research, and the reasons that larger funding entities ...
October 15, 2020
Webinar, hosted by HESI and the American Association of Pharmaceutical Scientists (AAPS)
Development and Regulatory Approval for Toxicogenomics Biomarker to Detect DNA Damage-Inducing Agents
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The HESI Protein Allergens, Toxins, and Bioinformatics (PATB) Committee is hosting a virtual workshop focusing on the state of the science for a wide array of protein toxins classes, MOAs, structures, activity, and general biology. Additionally, the workshop will cover the bioinformatics analysis of protein toxins and how to leverage computational biology for protein toxins identification/characterization, with in silico approaches.
The Protein Toxins Workshop will serve the dual purpose of learning from the experts in the field about the state of the science as well as assessing the translation of knowledge to practical applications, e.g., into weight-of-evidence approaches for the safety assessment of biotechnology products. The workshop aims to gain insight into how feasible/useful (or not) a protein toxin database could be in risk assessment/product development. This meeting will serve as an informational platform about HESI and will demonstrate the advances in protein toxins research, presented by international experts, and will help inform the development of novel approaches for the identification and classification of potential toxicity risk in novel proteins.
Details
- Date: Wednesday, 21 October 2020 - Thursday, 22 October 2020
- Time: 9:00 AM - 12:00 PM EST
- Registration: Details coming soon
Workshop Program Outline (subject to change)
Wednesday, 21 October 2020
- 9:00 AM - Opening Remarks (Dr. Laura Privalle, BASF Corporation)
- From protein toxins to biotechnology products
- Setting the stage; considerations for publication of meeting report
- 9:30 AM - Brief Codex Discussion
- Allergenicity assessment vs. toxins/toxicity assessment
- 10:00 AM - Terrestrial Toxins
- 11:30 AM - Marine Toxins
Thursday, 22 October 2020
- 9:00 AM - Bacterial Toxins
- 10:30 AM - Bioinformatics & Computational Biology in Protein Toxins Research
For more information, please contact the PATB Committee's Senior Scientific Program Manager, Dr. Lucilia Mouriès at lmouries@hesiglobal.org.
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