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						REGISTRATION HERE
					
			
						MEETING AGENDA
					
	Details

Location: Tivoli Hotel and Congress Center - Copenhagen, Denmark

Dates: October 17 - 18, 2018
There will also be another meeting at the Tivoli Hotel and Congress Center in Copenhagen, Denmark, called FAAM 2018, a EAACI Focused Meeting. FAAM 2018 will take place from 18 -20 October 2018. Please consider attending both events! Find more information on the event here.
 
About

In the growing field of allergy research, scientists can approach protein characterization and allergy hazard assessment in diverse ways. The Health and Environmental Sciences Institute (HESI) Protein Allergens, Toxins, and Bioinformatics (PATB) committee supports original basic research that seeks to uncover the interplay between protein allergenicity and the physicochemical properties of allergenic proteins. The PATB also oversees the creation, maintenance and distribution of the Comprehensive Protein Allergen Resource (COMPARE) Database whose use in conjunction bioinformatic tools, offers an effective means for assessing allergenic potential of novel food proteins.  PATB’s focus on basic allergy research, coupled with bioinformatic methods for allergenic hazard assessment is unique within the scientific community as it supports an ever-increasing awareness of allergenicity among consumers and regulators. Topics to be covered in this workshop will include historic aspects of food allergy assessment, the evolution of bioinformatics as it relates to allergy assessment, and recent changes in regulations regarding novel food proteins.
This educational workshop will cover advances in protein allergy research and inform the use of novel approaches for the identification of potential food allergens. This event will be of interest to government regulators, those involved in food allergy and celiac disease research, and scientists involved in food safety and risk assessment.
				
	
 
Objectives
Evaluate bioinformatics approaches to characterize the allergenicity potential of novel proteins and inform allergy safety assessment.
Discuss real-world examples of: 1) a product development case-study describing the utility of bioinformatics in protein characterization, and 2) a practical application of the EFSA 2017 Guidance.
Provide insights from new research, ranging from modifications of allergen epitopes at the single amino-acid level, to using protein structural modeling for allergenicity prediction, to the relation between enzymes and allergenic activity.
	
Introduction
Overview of contributions and research of the HESI PATB to Bioinformatics Analysis of the Potential Allergenicity of Novel Proteins 

Greg Ladics, Dupont (Download Presentation)
 
Session I: Bioinformatics Approaches to Protein Characterization and Allergy Safety Assessment


A history of bioinformatics: development of in silico approaches to evaluate food proteins 

Andre Silvanovich, Bayer Crop Science (Download Presentation)
Protein sequence analysis tools and resources to detect potential allergens 

Rob Finn, European Bioinformatics Institute (EBI) (Download Presentation)
Case Study: Allergenic risk of insect proteins

Kitty Verhoeckx, TNO (Download Presentation)
The COMPARE Allergen Database: a public, comprehensive protein allergen resource for allergenicity safety assessment

Lars Poulsen, University of Copenhagen (Download Presentation)
Novel methods to identify allergenicity potential of proteins 

Sebastian Maurer-Stroh, A*STAR Bioinformatics Institute (BII), Singapore (Download Presentation)
 
Session II: Other Considerations for Allergen Safety Assessment
The PATB “Allergen Rebuild Project”: can the conservative replacement of amino acids in an allergen epitope affect IgE binding and cross-reactivity? 

Ronald van Ree, Academic Medical Center, University of Amsterdam
Development of a Random Forest model for predicting allergenicity of new and modified proteins

Tanja Krone, TNO
Cross-reactive carbohydrate determinants and allergenicity  

Edzard Spillner, Aarhus University (Download Presentation)
 
Session III: Non-IgE Mediated Allergy 
Overview of known non-IgE mediated diseases and progress in immunology of non-IgE diseases 

Antonella Cianferoni, Children’s Hospital of Philadelphia (Download Presentation)
In silico tools to predict potential celiac disease toxicity 

Frits Koning, Leiden University (Download Presentation)
Application of EFSA 2017 bioinformatic guidance for non-IgE mediated immune disease 

Andre Silvanovich, Bayer Crop Science (Download Presentation)
Considerations for small peptide analyses in SGF 

Scott McClain, Syngenta (Download Presentation)

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The Gut Microbiome: Markers of Human Health, 
Drug Efficacy and Xenobiotic Toxicity
 
June 25 - 26
Holiday Inn & Suites Alexandria - Old Town

625 First Street

Alexandria, Virginia
	
The gut microbiome is believed to play an important role in human health in areas as diverse as brain function and the immune system.  Exploring host-microbiome interactions will provide a mechanistic understanding and enable new insights in human diseases (i.e., their diagnosis, prognosis and treatment) and new perceptions of xenobiotic efficacy and/or toxicity. This workshop will review the science and initiate discussions on multiple topics, including a) identification of biomarkers of toxicity for alterations in gut microbial function, b) if changes in the microbiome can affect efficacy of medicines and c) if exposure to xenobiotics can eventually result in a disease state through changes in the microbiome.  Conclusions from his workshop will help determine where the data gaps are so that researchers can start answering these questions.
WORKSHOP GOAL
To identify data gaps that can be addressed to help determine if alterations in the gut microbiome have an effect on human health.
				
	
WORKSHOP AIMS
1.  To discuss and review the current science on the gut microbiome and identify areas of interest regarding its role in human health
2.  To discuss our understanding on how xenobiotic toxicity affects the microbiome
3.  To understand if there are biomarkers of disease or organ damage due to:
     -  Alterations of microbiome structure and function
     -  Endogenous microbial metabolites
	
Workshop Agenda [Download Agenda]
Plenary
 
Drugging Gut Microbial Enzymes for the Treatment of Cardiometabolic Disease

Mark Brown, Cleveland Clinic                                                                      
Session 1: Biotransformation
Overview of Biotransformation of Xenobiotics by Microbiota
Julia Cui, University of Washington [Download Presentation]
 
Gut Microbial Transformation – Endogenous and Exogenous Metabolites & Effect of Xenobiotics on Microbial Composition and Endogenous Functions
Gary Perdew, Penn State University
 
Modification of Chemical Effects by Microbiome?
Andrew Patterson, Penn State University
 
Session 2: Biomarkers of Adverse Effects 
What is an Adverse Effect?
Rodney Dietert, Cornell University [Download Presentation]
 
Where to Look for Biomarkers?
Carrie Brodmerkel, Janssen [Download Presentation]
 
Challenges in Determining Sensitive Biomarkers of Dysbiosis When Assessing the Impact of Antimicrobial Drug Residues in Food on the Human Intestinal Microbiome
Carl Cerniglia, US FDA-NCTR [Download Presentation]
 
What are the Tools and Technologies Needed?
Joseph Petrosino, Baylor College of Medicine [Download Presentation]
 
Session 3: Biomarkers of Toxicity & Disease
Toxicity and Environmental Pollutants
Kun Lu, University of North Carolina Chapel Hill
 
Identification of Microbiome-based Biomarkers and Challenges Associated with their Application: Case Studies from Obesity, IBD, and Cancer
Emily Hollister, Diversigen [Download Presentation]
 
The Microbiome and Hypertension 
Elaine Richards Sumners, University of Florida [Download Presentation]
 
Session 4: Human Susceptibility
Health Insights from Microbiomes in the Context of Personal, Dense, Dynamic, Data Clouds 
Nathan Price, Institute for Systems Biology
 
Age – Early & Late Life
Eugene Chang, University of Chicago [Download Presentation]
 
Gender and the Gut Microbiome
Marijke Faas, University of Groningen
 
Session 5: Key Animal Models
Overview of Key Factors Known to Affect Composition of Laboratory Rodent Gut Microbiome
Aaron Ericsson, University of Missouri [Download Presentation]
 
Natural World Versus Laboratory World: Natural Gut Microbiota from Wild Mice Improve Host Fitness in Viral Infection and Carcinogenesis Models
Barbara Rehermann, NIH/NIDDK [Download Presentation]
 
Investigating Interactions Between Chemicals and Microbiota in Zebrafish
Tamara Tal, US EPA
 

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