Risk Assessment in the 21st Century (RISK21) Committee

Mission Statement

The committee’s mission is to promote a transparent, purpose-driven, structured approach to risk assessment based on key principles, including problem formulation, tiered integration of both hazard and exposure at each step, and fit for purpose.

Version 2.0 of the RISK21 webtool is now available. To access the RISK21 webtool, please visit risk21.org.

 

Working Groups

  • Brazil Pesticide Use Information Tool

    The Committee contracted out the development of a database of information necessary to estimate pesticide exposure (and obtain parameters for exposure models) in Brazil. Pesticide use and application information are being extracted from the Brazilian Health Regulatory Agency (ANVISA) monographs and from Agrofit, Brazil’s pesticide registration tool, and pulled into an easily searchable, publicly accessible database.

    A project advisory team is monitoring and supporting the project, which is expected to be completed in the first quarter of 2023.

  • Argentina Pesticide Residue Information Tool

    A tool developed to inform pesticide residues in food in Argentina was funded and developed for SENASA. It resulted from a partnership between HESI, Buenos Aires and Austral Universities, and SENASA. A manuscript co-authored by all partners and featuring this effort will be developed in the coming year.

  • Pesticide Labeling Harmonization

    Initiated discussion to explore how to better harmonize pesticide labels by:

    • Identifying the needs across various countries/regions
    • Communicating ongoing work in this space (e.g., smart labels, e-labels, etc.) within and outside of OECD (webinar will be scheduled in Q4 2022 to share updates)
    • Working to identify potential partnerships
  • RISK21 Toolkit Update

    Discussions have been initiated to improve both the RAFT tool and RISK21 matrix and make them more user-friendly.

HESI Staff

Committee Events

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Committee Publications

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Using Exposure Bands for Rapid Decision Making in the RISK21 Tiered Exposure Assessment

Critical Reviews in Toxicology, 2017

Dellarco M, Zaleski R, Gaborek BJ, Qian H, Bellin CA, Egeghy P, ...

The Health and Environmental Sciences Institute (HESI) Risk Assessment in the 21st Century (RISK21) Committee was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent ...

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A Framework for Cumulative Risk Assessment in the 21st Century

Critical Reviews in Toxicology, 2016

Moretto A, Bachman A, Boobis A, Solomon KR, Pastoor TP, Wilks MF, ...

The Health and Environmental Sciences Institute (HESI) has developed a framework to support a transition in the way in which information for chemical risk assessment is obtained and used. The approach is based on detailed problem formulation, where exposure drives the data acquisition process in order to enable informed ...

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Problem Formulation for Risk Assessment of Combined Exposures to Chemicals and Other Stressors in Humans

Critical Reviews in Toxicology, 2016

Solomon KR, Wilks MF, Bachman A, Boobis A, Moretto A, Pastoor TP, ...

When the human health risk assessment/risk management paradigm was developed, it did not explicitly include a “problem formulation” phase. The concept of problem formulation was first introduced in the context of ecological risk assessment (ERA) for the pragmatic reason to constrain and focus ERAs on the key questions. ...

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Use of the RISK21 Roadmap and Matrix: Human Health Risk Assessment of the Use of a Pyrethroid in Bed Netting

Critical Reviews in Toxicology , 2015

Doe JE, Lander DR, Doerrer NG, Heard N, Hines RN, Lowit AB, ...
  • HESI - Health and Environmental Sciences Institute

The HESI-coordinated RISK21 roadmap and matrix are tools that provide a transparent method to compare exposure and toxicity information and assess whether additional refinement is required to obtain the necessary precision level for a decision regarding safety.

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Risk Assessment in the 21st Century: Roadmap and Matrix

Critical Reviews in Toxicology, 2014

Embry MR, Bachman AN, Bell DR, Boobis AR, Cohen SM, Dellarco M, ...
  • HESI - Health and Environmental Sciences Institute

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix.

Read more

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