Risk Assessment in the 21st Century (RISK21) Committee

Mission Statement

The committee’s mission is to promote a transparent, purpose-driven, structured approach to risk assessment based on key principles, including problem formulation, tiered integration of both hazard and exposure at each step, and fit for purpose.

Version 2.0 of the RISK21 webtool is now available. To access the RISK21 webtool, please visit risk21.org.

Working Groups

  • Risk Assessment Summit Organization Team

    This group helped organize the Risk Assessment Summit, which was held in Washington, DC, on 18–19 February 2020. The summit successfully convened a broad group of stakeholders to discuss risk assessment approaches that ascribe to the following general principles:

    • Problem formulation–based
    • Risk-based at each step
    • Fit for purpose
    • Utilization of existing information
    • Transparent
    • Visual

    The meeting provided a forum to discuss risk assessment challenges, foster collaboration, and leverage expertise to address gaps and needs in the risk assessment space. It also provided an opportunity for participants to share their experience with the community of practice. The team helped with strategic development and outreach.

  • Exposure Group

    This group initiated a conversation around the development of a strategic plan that links to ongoing RISK21 and other efforts, with an eye toward the integration of state-of-the-art science in exposure assessments.

  • Brazil Pesticide Prioritization Work

    The committee contracted out the development of a database of information necessary to estimate pesticide exposure (and obtain parameters for exposure models) in Brazil. Pesticide use and application information are being extracted from the Brazilian Health Regulatory Agency (ANVISA) monographs and from Agrofit, Brazil’s pesticide registration tool, and pulled into an easily searchable, publicly accessible database. A project advisory team is monitoring and supporting the project, which is expected to be completed in 1Q 2021.

  • South America Outreach

    An informal team, focused on developing outreach in Colombia and Argentina, developed organically in 2020. This team is exploring opportunities to:

    • Collaborate with the Colombian Ministry of Health to prioritize contaminants in drinking water using the RISK21 approach,
    • Help the National Food Safety and Quality Service (SENASA) in Argentina with the development of an exposure database similar to the one being developed in Brazil, and
    • Develop and deliver a RISK21 training in Spanish at the University of Buenos Aires.

HESI Staff

Committee Events

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Committee Publications

Filter

Using Exposure Bands for Rapid Decision Making in the RISK21 Tiered Exposure Assessment

The Health and Environmental Sciences Institute (HESI) Risk Assessment in the 21st Century (RISK21) Committee was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent ...

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A Framework for Cumulative Risk Assessment in the 21st Century

The Health and Environmental Sciences Institute (HESI) has developed a framework to support a transition in the way in which information for chemical risk assessment is obtained and used. The approach is based on detailed problem formulation, where exposure drives the data acquisition process in order to enable informed ...

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Problem Formulation for Risk Assessment of Combined Exposures to Chemicals and Other Stressors in Humans

When the human health risk assessment/risk management paradigm was developed, it did not explicitly include a “problem formulation” phase. The concept of problem formulation was first introduced in the context of ecological risk assessment (ERA) for the pragmatic reason to constrain and focus ERAs on the key questions. ...

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Risk Assessment in the 21st Century: Roadmap and Matrix

The RISK21 integrated evaluation strategy is a problem formulation-based exposure-driven risk assessment roadmap that takes advantage of existing information to graphically represent the intersection of exposure and toxicity data on a highly visual matrix.

Read more

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