Protein Allergens, Toxins, and Bioinformatics (PATB) Committee

Mission Statement

The PATB is committed to advancing the scientific understanding of the relevant parameters defining allergenic proteins and protein toxins, and encouraging the development of reliable and accurate methodologies for characterizing the allergenic potential of novel proteins in order to leverage the potential of bioinformatics approaches in accomplishing these efforts.

Renaming the Committee: PATC to PATB

Formerly the Protein Allergenicity Technical Committee (PATC), the committee has adopted a new designation, the Protein Allergens, Toxins and Bioinformatics (PATB) Committee, to embrace a broader scope, expertise, interests, and collaborators in the fields of bioinformatics and protein toxins, while strengthening its core focus in allergenicity.

Working Groups

  • Celiac Disease

    Project initiated in October 2023. A call for participants was released by the committee during Summer 2023 and a team 10 participants from 9 organizations has been assembled. This pilot study will test the potential of microbial derived peptides to mimic gluten peptides in activating early events in the cascade triggering Celiac Disease, using organoid models derived from Celiac patients and healthy individuals. The committee is aiming to evaluate the clinical relevance of non-gluten peptides that share similarity with the disease-causing gluten peptides, in triggering Celiac disease. Experimental work will be conducted thanks to a collaboration with leading Celiac Disease experts at Massachusetts General Hospital.

  • Digestibility Working Group: Food Matrix Project

    This research project aims to study the impact of food matrices on the digestibility of proteins and complements the work completed on digestibility in vitro models, by testing whether protocols that take matrices into account would provide a better discrimination of allergens and nonallergens than protocols focusing on purified proteins in solution. In 2020, the experimental work was concluded. The data are being analyzed and a publication is planned in 2021.

  • Immunogenicity

    This working group aims to examine application of an in vitro protocol for identifying specific T-cells and antibodies from nonallergic and allergic patients to pairs of proteins from the same protein family but with different allergenicity. After some delays in the anticipated start date due to the COVID-19 pandemic, the project officially received the green light from the leading institution, Copenhagen University Hospital at Gentofte (Copenhagen, Denmark) in late 2020.

  • Protein Toxins Task Force

    The goals of the task force are to (1) investigate approaches for identifying protein toxins and (2) suggest specific guidelines to identify new protein toxins. In 2019, the task force undertook a literature review to identify current approaches being used and leading experts in the topic to design the workshop held in 2020. The workshop covered recent advances in protein toxins biology, described the use of computational biology for protein toxins identification and characterization with in silico approaches, and discussed the applicability of existing tools and resources for safety assessment of novel food biotechnology products.

  • COMPARE Allergen Database

    Development and annual update of a database of protein allergen sequences is ongoing. The eighth version of the database was released in January 2024. Throughout the year, the team re-initiates and conducts the 10-month-long process leading to the next annual update of the COMPARE Database. Visit COMPARE at https://comparedatabase.org for more details.

HESI Staff

Leadership Team

  • Ronald van Ree, PhD

    Academic Medical Center, University of Amsterdam

  • Andre Silvanovich, PhD

    Retired from Bayer CropScience

Committee Events

PATC Non-IgE Mediated Immune Reactions to Foods Workshop

Rome, Italy

This workshop provided an opportunity to discuss the current state of the science in immunologic mechanisms of non-IgE mediated food allergy with a specific emphasis on use of these data to assess food safety.

Read more

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				FAAM Workshop Logo_revised large 4
			
						REGISTRATION HERE
					
			
						MEETING AGENDA
					
	Details
Location: Tivoli Hotel and Congress Center - Copenhagen, Denmark
Dates: October 17 - 18, 2018

There will also be another meeting at the Tivoli Hotel and Congress Center in Copenhagen, Denmark, called FAAM 2018, a EAACI Focused Meeting. FAAM 2018 will take place from 18 -20 October 2018. Please consider attending both events! Find more information on the event here.

 

About
In the growing field of allergy research, scientists can approach protein characterization and allergy hazard assessment in diverse ways. The Health and Environmental Sciences Institute (HESI) Protein Allergens, Toxins, and Bioinformatics (PATB) committee supports original basic research that seeks to uncover the interplay between protein allergenicity and the physicochemical properties of allergenic proteins. The PATB also oversees the creation, maintenance and distribution of the Comprehensive Protein Allergen Resource (COMPARE) Database whose use in conjunction bioinformatic tools, offers an effective means for assessing allergenic potential of novel food proteins.  PATB’s focus on basic allergy research, coupled with bioinformatic methods for allergenic hazard assessment is unique within the scientific community as it supports an ever-increasing awareness of allergenicity among consumers and regulators. Topics to be covered in this workshop will include historic aspects of food allergy assessment, the evolution of bioinformatics as it relates to allergy assessment, and recent changes in regulations regarding novel food proteins.

This educational workshop will cover advances in protein allergy research and inform the use of novel approaches for the identification of potential food allergens. This event will be of interest to government regulators, those involved in food allergy and celiac disease research, and scientists involved in food safety and risk assessment.

dreamstime_xl_71979237

 

Objectives

Evaluate bioinformatics approaches to characterize the allergenicity potential of novel proteins and inform allergy safety assessment.

Discuss real-world examples of: 1) a product development case-study describing the utility of bioinformatics in protein characterization, and 2) a practical application of the EFSA 2017 Guidance.

Provide insights from new research, ranging from modifications of allergen epitopes at the single amino-acid level, to using protein structural modeling for allergenicity prediction, to the relation between enzymes and allergenic activity.

Introduction

Overview of contributions and research of the HESI PATB to Bioinformatics Analysis of the Potential Allergenicity of Novel Proteins
Greg Ladics, Dupont (Download Presentation)

 

Session I: Bioinformatics Approaches to Protein Characterization and Allergy Safety Assessment
A history of bioinformatics: development of in silico approaches to evaluate food proteins 
Andre Silvanovich, Bayer Crop Science (Download Presentation) Protein sequence analysis tools and resources to detect potential allergens
Rob Finn, European Bioinformatics Institute (EBI) (Download Presentation) Case Study: Allergenic risk of insect proteins
Kitty Verhoeckx, TNO (Download Presentation) The COMPARE Allergen Database: a public, comprehensive protein allergen resource for allergenicity safety assessment
Lars Poulsen, University of Copenhagen (Download Presentation) Novel methods to identify allergenicity potential of proteins
Sebastian Maurer-Stroh, A*STAR Bioinformatics Institute (BII), Singapore (Download Presentation)

 

Session II: Other Considerations for Allergen Safety Assessment

The PATB “Allergen Rebuild Project”: can the conservative replacement of amino acids in an allergen epitope affect IgE binding and cross-reactivity?
Ronald van Ree, Academic Medical Center, University of Amsterdam Development of a Random Forest model for predicting allergenicity of new and modified proteins
Tanja Krone, TNO Cross-reactive carbohydrate determinants and allergenicity 
Edzard Spillner, Aarhus University (Download Presentation)

 

Session III: Non-IgE Mediated Allergy

Overview of known non-IgE mediated diseases and progress in immunology of non-IgE diseases
Antonella Cianferoni, Children’s Hospital of Philadelphia (Download Presentation) In silico tools to predict potential celiac disease toxicity 
Frits Koning, Leiden University (Download Presentation) Application of EFSA 2017 bioinformatic guidance for non-IgE mediated immune disease
Andre Silvanovich, Bayer Crop Science (Download Presentation) Considerations for small peptide analyses in SGF
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Location: Tivoli Hotel and Congress Center - Copenhagen, Denmark
Dates: October 17 - 18, 2018

There will also be another meeting at the Tivoli Hotel and Congress Center in Copenhagen, Denmark, called FAAM 2018, a EAACI Focused Meeting. FAAM 2018 will take place from 18 -20 October 2018. Please consider attending both events! Find more information on the event here.

 

About
In the growing field of allergy research, scientists can approach protein characterization and allergy hazard assessment in diverse ways. The Health and Environmental Sciences Institute (HESI) Protein Allergens, Toxins, and Bioinformatics (PATB) committee supports original basic research that seeks to uncover the interplay between protein allergenicity and the physicochemical properties of allergenic proteins. The PATB also oversees the creation, maintenance and distribution of the Comprehensive Protein Allergen Resource (COMPARE) Database whose use in conjunction bioinformatic tools, offers an effective means for assessing allergenic potential of novel food proteins.  PATB’s focus on basic allergy research, coupled with bioinformatic methods for allergenic hazard assessment is unique within the scientific community as it supports an ever-increasing awareness of allergenicity among consumers and regulators. Topics to be covered in this workshop will include historic aspects of food allergy assessment, the evolution of bioinformatics as it relates to allergy assessment, and recent changes in regulations regarding novel food proteins.

This educational workshop will cover advances in protein allergy research and inform the use of novel approaches for the identification of potential food allergens. This event will be of interest to government regulators, those involved in food allergy and celiac disease research, and scientists involved in food safety and risk assessment.

dreamstime_xl_71979237

 

Objectives

Evaluate bioinformatics approaches to characterize the allergenicity potential of novel proteins and inform allergy safety assessment.

Discuss real-world examples of: 1) a product development case-study describing the utility of bioinformatics in protein characterization, and 2) a practical application of the EFSA 2017 Guidance.

Provide insights from new research, ranging from modifications of allergen epitopes at the single amino-acid level, to using protein structural modeling for allergenicity prediction, to the relation between enzymes and allergenic activity.

Introduction

Overview of contributions and research of the HESI PATB to Bioinformatics Analysis of the Potential Allergenicity of Novel Proteins
Greg Ladics, Dupont (Download Presentation)

 

Session I: Bioinformatics Approaches to Protein Characterization and Allergy Safety Assessment
A history of bioinformatics: development of in silico approaches to evaluate food proteins 
Andre Silvanovich, Bayer Crop Science (Download Presentation) Protein sequence analysis tools and resources to detect potential allergens
Rob Finn, European Bioinformatics Institute (EBI) (Download Presentation) Case Study: Allergenic risk of insect proteins
Kitty Verhoeckx, TNO (Download Presentation) The COMPARE Allergen Database: a public, comprehensive protein allergen resource for allergenicity safety assessment
Lars Poulsen, University of Copenhagen (Download Presentation) Novel methods to identify allergenicity potential of proteins
Sebastian Maurer-Stroh, A*STAR Bioinformatics Institute (BII), Singapore (Download Presentation)

 

Session II: Other Considerations for Allergen Safety Assessment

The PATB “Allergen Rebuild Project”: can the conservative replacement of amino acids in an allergen epitope affect IgE binding and cross-reactivity?
Ronald van Ree, Academic Medical Center, University of Amsterdam Development of a Random Forest model for predicting allergenicity of new and modified proteins
Tanja Krone, TNO Cross-reactive carbohydrate determinants and allergenicity 
Edzard Spillner, Aarhus University (Download Presentation)

 

Session III: Non-IgE Mediated Allergy

Overview of known non-IgE mediated diseases and progress in immunology of non-IgE diseases
Antonella Cianferoni, Children’s Hospital of Philadelphia (Download Presentation) In silico tools to predict potential celiac disease toxicity 
Frits Koning, Leiden University (Download Presentation) Application of EFSA 2017 bioinformatic guidance for non-IgE mediated immune disease
Andre Silvanovich, Bayer Crop Science (Download Presentation) Considerations for small peptide analyses in SGF
Scott McClain, Syngenta (Download Presentation) [post_title] => Bioinformatics Approaches to Assess Safety of Novel Proteins in Relation to Food Hypersensitivity [post_excerpt] => [post_status] => publish [comment_status] => closed [ping_status] => closed [post_password] => [post_name] => bioinformatics-approaches-to-assess-safety-of-novel-proteins-in-relation-to-food-hypersensitivity [to_ping] => [pinged] => [post_modified] => 2020-10-28 15:19:22 [post_modified_gmt] => 2020-10-28 15:19:22 [post_content_filtered] => [post_parent] => 0 [guid] => https://hesiglobal.org/?post_type=event&p=7223 [menu_order] => 0 [post_type] => event [post_mime_type] => [comment_count] => 0 [filter] => raw ) [comment_count] => 0 [current_comment] => -1 [found_posts] => 25 [max_num_pages] => 5 [max_num_comment_pages] => 0 [is_single] => [is_preview] => [is_page] => [is_archive] => 1 [is_date] => [is_year] => [is_month] => [is_day] => [is_time] => [is_author] => [is_category] => [is_tag] => 1 [is_tax] => [is_search] => [is_feed] => [is_comment_feed] => [is_trackback] => [is_home] => [is_privacy_policy] => [is_404] => [is_embed] => [is_paged] => 1 [is_admin] => [is_attachment] => [is_singular] => [is_robots] => [is_favicon] => [is_posts_page] => [is_post_type_archive] => [query_vars_hash:WP_Query:private] => 942dad68c18a595a6669385e1bdf1d45 [query_vars_changed:WP_Query:private] => [thumbnails_cached] => [allow_query_attachment_by_filename:protected] => [stopwords:WP_Query:private] => [compat_fields:WP_Query:private] => Array ( [0] => query_vars_hash [1] => query_vars_changed ) [compat_methods:WP_Query:private] => Array ( [0] => init_query_flags [1] => parse_tax_query ) )

Committee Publications

“From Protein Toxins to Applied Toxicological Testing” virtual workshop identifies the need for a bioinformatic framework to assess novel food protein safety

The HESI Protein Allergens, Toxins, and Bioinformatics Committee, and the Society of Toxicology Food Safety Specialty Section co-hosted a virtual workshop titled “From Protein Toxins to Applied Toxicological Testing”.  Key outcomes of the workshop are highlighted here.

Read more

Variation in Seed Allergen Content From Three Varieties of Soybean Cultivated in Nine Different Locations in Iowa, Illinois, and Indiana

Soybean (Glycine max) is an important food stock, and also considered an allergenic food with at least eight well characterized allergens. However, it is a less prevalent allergen source than many other foods and is rarely life-threatening. Soybean is incorporated into commonly consumed foods, and therefore, the allergens pose ...

Read more

The COMPARE Database: A Public Resource for Allergen Identification, Adapted for Continuous Improvement

The availability of databases identifying allergenic proteins via a transparent and consensus-based scientific approach is of prime importance to support the safety review of genetically-modified foods and feeds, and public safety in general. Over recent years, screening for potential new allergens sequences has become ...

Read more

Sensitizing Properties of Proteins: Executive Summary

The scope of allergy risk is diverse considering the myriad ways in which protein allergenicity is affected by physiochemical characteristics of proteins.

Read more

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