Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy

Journal of Pharmacological and Toxicological Methods, 2021

Pugsley MK, Brooks MB, Fishman CE, Katavolos P, Chiang AY, ...

Zucker diabetic fatty (ZDF) rats are used widely as an animal model of metabolic syndrome and insulin resistance. Our study focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats (fa/fa), including biomarkers to detect early signs of hypercoagulability and vascular injury ...

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Use of Trophic Magnification Factors and Related Measures to Characterize Bioaccumulation Potential of Chemicals

Integrated Environmental Assessment and Management, 2012

Conder JM, Gobas FA, Borgå K, Muir DC, Powell DE
  • HESI - Health and Environmental Sciences Institute

Recent technical workgroups have concluded that trophic magnification factors (TMFs) are useful in characterizing the bioaccumulation potential of a chemical, because TMFs provide a holistic measure of biomagnification in food webs.

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Using Exposure Bands for Rapid Decision Making in the RISK21 Tiered Exposure Assessment

Critical Reviews in Toxicology, 2017

Dellarco M, Zaleski R, Gaborek BJ, Qian H, Bellin CA, Egeghy P, ...

The Health and Environmental Sciences Institute (HESI) Risk Assessment in the 21st Century (RISK21) Committee was initiated to address and catalyze improvements in human health risk assessment. RISK21 is a problem formulation-based conceptual roadmap and risk matrix visualization tool, facilitating transparent ...

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Using Mode of Action Information to Improve Regulatory Decision-Making: An ECETOC/HESI Workshop Overview

Critical Reviews in Toxicology, 2011

Carmichael N, Bausen M, Boobis AR, Cohen SM, Embry M, ...
  • HESI - Health and Environmental Sciences Institute

The European Centre for Ecotoxicology and Toxicology of Chemicals (ECETOC) and the Health and Environmental Sciences Institute (HESI) hosted a workshop in November 2009 to review current practice in the application of mode of action (MOA) considerations in chemical risk assessment.

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Utility of a next-generation framework for assessment of genomic damage: A case study using the pharmaceutical drug candidate etoposide

Environmental and Molecular Mutagenesis, 2021

Nicolette J, Luijten M, Sasaki JC, Custer L, Embry M, Froetschl R, ...

The HESI Genetic Toxicology Technical Committee (GTTC) applies their systematic and flexible approach for assessing the risk of genetic damage due to exposure to chemical substances to etoposide, a drug used in certain types of cancer treatments, as a representative pharmaceutical case study.

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Utilization of Juvenile Animal Studies to Determine the Human Effects and Risks of Environmental Toxicants During Postnatal Developmental Stages

Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2004

Brent RL
  • HESI - Health and Environmental Sciences Institute

Toxicology studies utilizing animals and in vitro cellular or tissue preparations have been used to study the toxic effects and mechanism of action of drugs and chemicals and to determine the effective and safe dose of drugs in humans and the risk of toxicity from chemical exposures.

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