Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Dose-Dependent Transitions in Mechanisms of Toxicity: Case Studies

Toxicology and Applied Pharmacology, 2004

Slikker W, Andersen ME, Bogdanffy MS, Bus JS, Cohen SD, ...
  • HESI - Health and Environmental Sciences Institute

Experience with dose response and mechanisms of toxicity has shown that multiple mechanisms may exist for a single agent along the continuum of the full dose–response curve.

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Drug Discovery and Development: Biomarkers of Neurotoxicity and Neurodegeneration

Experimental Biology and Medicine, 2018

Walker AL, Imam SZ, & Roberts RA

Attrition in drug discovery and development remains a major challenge. Safety/toxicity is the most prevalent reason for failure with cardiovascular and CNS toxicities predominating. Non-invasive biomarkers of neurotoxicity would provide significant advantage by allowing earlier prediction of likely neurotoxicity in ...

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Echocardiographic and Hemodynamic Indices of Myocardial Contractility Simultaneously Evaluated in Telemetered Beagle Dogs: A HESI-Sponsored Cross-Company Evaluation

Journal of Pharmacological and Toxicological Methods, 2020

Rossman EI, Cools F, Cordes J, Dhuyvetter D, Doyle JM, ...
  • HESI - Health and Environmental Sciences Institute

Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically invasive and their translation to human measures of cardiac function are not well defined. Clinically, cardiac ...

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Health and Environmental Sciences Institute (HESI)

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