Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Demodifying RNA for Transcriptomic Analyses of Archival Formalin-Fixed Paraffin-Embedded Samples

Toxicological Sciences, 2017

Wehmas LC, Wood CE, Gagne R, Williams A, Yauk C, Gosink MM, ...

Archival formalin-fixed paraffin-embedded (FFPE) tissue samples offer a vast but largely untapped resource for genomic research. The primary technical issues limiting use of FFPE samples are RNA yield and quality. In this study, we evaluated methods to demodify RNA highly fragmented and crosslinked by formalin fixation. ...

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Can Nonclinical Repolarization Assays Predict the Results of Clinical Thorough QT Studies? Results from a Research Consortium.

British Journal of Pharmacology, 2017

Park EJ, Gintant GA, Bi D, Kozeli D, Pettit SD, Pierson JB, ...
  • HESI - Health and Environmental Sciences Institute

The strengths and limitations of three nonclinical repolarization assays used to define the risk of clinical drug-induced delayed ventricular repolarization (a surrogate marker of the rare but potentially lethal arrhythmia Torsades de Pointes) were compared during a retrospective analysis of an anonymized database of 150 ...

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Analysis of Negative Historical Control Group Data from the In Vitro Micronucleus Assay Using TK6 Cells

Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 2017

Lovell DP, Fellows M, Marchetti F, Christiansen J, Elhajouji A, ...

The recent revisions of the Organisation for Economic Co-operation and Development (OECD) genetic toxicology test guidelines emphasize the importance of historical negative controls both for data quality and interpretation. The goal of a HESI Genetic Toxicology (GTTC) Committee workgroup was to collect data from ...

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Changes in the Metabolome and microRNA Levels in Biological Fluids Might Represent Biomarkers of Neurotoxicity: A Trimethyltin Study

Experimental Biology and Medicine, 2017

Imam SZ, He Z, Cuevas E, Rosas-Hernandez H, Lantz SM, Sarkar S, ...

Neurotoxicity has been linked with exposure to a number of common drugs and chemicals, yet efficient, accurate, and minimally invasive methods to detect it are lacking. Fluid-based biomarkers such as those found in serum, plasma, urine, and cerebrospinal fluid have great potential due to the relative ease of sampling but at ...

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Development and Validation of a High-Throughput Transcriptomic Biomarker to Address 21st Century Genetic Toxicology Needs

Proceedings of the National Academy of Sciences, 2017

Li HH, Chen R, Hyduke DR, Williams A, Frötschl R, ...

Interpretation of positive genotoxicity findings using the current in vitro testing battery is a major challenge to industry and regulatory agencies. These tests, especially mammalian cell assays, have high sensitivity but suffer from low specificity, leading to high rates of irrelevant positive findings (i.e., positive ...

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Health and Environmental Sciences Institute (HESI)

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