Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals

Regulatory Toxicology and Pharmacology, 2000

Olson H, Betton G, Robinson D, Thomas K, Monro A, Kolaja G, ...
  • HESI - Health and Environmental Sciences Institute

This report summarizes the results of a multinational pharmaceutical company survey and the outcome of an International Life Sciences Institute (ILSI) Workshop (April 1999), which served to better understand concordance of the toxicity of pharmaceuticals observed in humans with that observed in experimental animals.

Read more

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in Pharmacology, 2019

Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, ...
  • HESI - Health and Environmental Sciences Institute

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects earlier in drug research using ...

Read more

Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in Pharmacology, 2019

Ribeiro A, Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, ...

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the prediction of clinical cardiac drug ...

Read more

Considerations towards the better integration of epidemiology into quantitative risk assessment

Global Epidemiology, 2022

Déglin SE, Burstyn I, Chen CL, Miller DJ, Gribble MO, Hamade AK, ...

This paper summarizes five key ideas that emerged from multi-sectoral and multi-stakeholder activities of HESI's Environmental Epidemiology for Risk Assessment Committee that could help improve how human data inform quantitative health risk assessment and decision making. It highlights the needs for concerted efforts from ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 20
            [orderby] => title
            [order] => ASC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 20
            [orderby] => title
            [order] => ASC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts 
					WHERE 1=1  AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					
					ORDER BY wp_posts.post_title ASC
					LIMIT 114, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 3476
                    [post_author] => 6
                    [post_date] => 2016-06-28 13:11:17
                    [post_date_gmt] => 2016-06-28 18:11:17
                    [post_content] => 
                    [post_title] => Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => concordance-of-the-toxicity-of-pharmaceuticals-in-humans-and-in-animals
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-28 13:11:17
                    [post_modified_gmt] => 2016-06-28 18:11:17
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3476
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 22513
                    [post_author] => 2
                    [post_date] => 2020-03-25 07:46:39
                    [post_date_gmt] => 2020-03-25 12:46:39
                    [post_content] => 
                    [post_title] => Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => considerations-for-an-in-vitro-cell-based-testing-platform-for-detection-of-adverse-drug-induced-inotropic-effects-in-early-drug-development-part-1-general-considerations-for-development-of-novel-t
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-03-25 07:46:39
                    [post_modified_gmt] => 2020-03-25 12:46:39
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=22513
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 22514
                    [post_author] => 2
                    [post_date] => 2020-03-25 07:49:14
                    [post_date_gmt] => 2020-03-25 12:49:14
                    [post_content] => 
                    [post_title] => Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => considerations-for-an-in-vitro-cell-based-testing-platform-for-detection-of-drug-induced-inotropic-effects-in-early-drug-development-part-2-designing-and-fabricating-microsystems-for-assaying-cardi
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-10-28 13:30:09
                    [post_modified_gmt] => 2020-10-28 13:30:09
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=22514
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 25781
                    [post_author] => 16
                    [post_date] => 2022-09-13 13:38:53
                    [post_date_gmt] => 2022-09-13 13:38:53
                    [post_content] => 
                    [post_title] => Considerations towards the better integration of epidemiology into quantitative risk assessment
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => considerations-towards-the-better-integration-of-epidemiology-into-quantitative-risk-assessment
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2022-09-13 14:25:04
                    [post_modified_gmt] => 2022-09-13 14:25:04
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=25781
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 3472
                    [post_author] => 6
                    [post_date] => 2016-06-28 13:07:29
                    [post_date_gmt] => 2016-06-28 18:07:29
                    [post_content] => 
                    [post_title] => Correlation of Suppressed Natural Killer Cell Activity With Altered Host Resistance Models in B6C3F1 Mice
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => correlation-of-suppressed-natural-killer-cell-activity-with-altered-host-resistance-models-in-b6c3f1-mice
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-28 13:07:29
                    [post_modified_gmt] => 2016-06-28 18:07:29
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3472
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 3274
                    [post_author] => 6
                    [post_date] => 2016-06-20 22:37:35
                    [post_date_gmt] => 2016-06-21 03:37:35
                    [post_content] => 
                    [post_title] => Creating Context for the Use of DNA Adduct Data in Cancer Risk Assessment: I. Data Organization
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => creating-context-for-the-use-of-dna-adduct-data-in-cancer-risk-assessment-i-data-organization
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 22:37:35
                    [post_modified_gmt] => 2016-06-21 03:37:35
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3274
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 3476
            [post_author] => 6
            [post_date] => 2016-06-28 13:11:17
            [post_date_gmt] => 2016-06-28 18:11:17
            [post_content] => 
            [post_title] => Concordance of the Toxicity of Pharmaceuticals in Humans and in Animals
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => concordance-of-the-toxicity-of-pharmaceuticals-in-humans-and-in-animals
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-06-28 13:11:17
            [post_modified_gmt] => 2016-06-28 18:11:17
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=3476
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 479
    [max_num_pages] => 80
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 3babaa68a70219aa4bcc4e6626bb2be4
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.