Environmental Toxicology and Chemistry, 2020
Salvito D, Fernandez M, Jenner K, Lyon DY, de Knecht J, Mayer P, ...
- HESI - Health and Environmental Sciences Institute
Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) pose unique risk assessment challenges to regulators and to product registrants. These substances can contain many constituents, sometimes partially unknown and/or variable, depending on fluctuations in their ...
Pharmaceutics, 2020
Van den Anker JN, McCune S, Annaert P, Baer GR, Mulugeta Y, ...
- HESI - Health and Environmental Sciences Institute
Drug dosing in neonates should be based on integrated knowledge concerning the disease to be treated, the physiological characteristics of the neonate, and the pharmacokinetics (PK) and pharmacodynamics (PD) of a given drug. It is critically important that all sources of information be leveraged to optimize dose selection for ...
Journal of Pharmacological and Toxicological Methods, 2020
Rossman EI, Cools F, Cordes J, Dhuyvetter D, Doyle JM, ...
- HESI - Health and Environmental Sciences Institute
Alterations in cardiac contractility can have significant clinical implications, highlighting the need for early detection of potential liabilities. Pre-clinical methods to assess contractility are typically invasive and their translation to human measures of cardiac function are not well defined. Clinically, cardiac ...
Toxicological Sciences, 2020
Sutherland VL, McQueen CA, Mendrick D, Gulezian D, Cerniglia C, ...
- HESI - Health and Environmental Sciences Institute
There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, HESI held a workshop, “The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity” to identify data gaps in determining how gut ...
Regulatory Toxicology and Pharmacology, 2020
Tan YM, Chan M, Chukwudebe A, Domoradzki J, Fisher J, Hack CE, ...
- HESI - Health and Environmental Sciences Institute
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their emergence, only a handful of models have been accepted to support regulatory ...
EMBO Molecular Medicine, 2020
Pettit SD, Jerome KR, Rouquie D, Mari B, Barbry P, Kanda Y, ...
- HESI - Health and Environmental Sciences Institute
Current demand for SARS‐CoV‐2 testing is straining material resource and labor capacity around the globe. As a result, the public health and clinical community are hindered in their ability to monitor and contain the spread of COVID‐19. Despite broad consensus that more testing is needed, pragmatic guidance towards ...
WP_Query Object
(
[query] => Array
(
[post_type] => publication
[posts_per_page] => 6
[type] =>
[area] =>
[committee] =>
[authors] => true
[showtitle] => false
[meta_query] => Array
(
[relation] => AND
)
[tax_query] => Array
(
)
[paged] => 13
[meta_key] => _ilsi_date
[orderby] => meta_value
[order] => DESC
)
[query_vars] => Array
(
[post_type] => publication
[posts_per_page] => 6
[type] =>
[area] =>
[committee] =>
[authors] => true
[showtitle] => false
[meta_query] => Array
(
[relation] => AND
)
[tax_query] => Array
(
)
[paged] => 13
[meta_key] => _ilsi_date
[orderby] => meta_value
[order] => DESC
[error] =>
[m] =>
[p] => 0
[post_parent] =>
[subpost] =>
[subpost_id] =>
[attachment] =>
[attachment_id] => 0
[name] =>
[pagename] =>
[page_id] => 0
[second] =>
[minute] =>
[hour] =>
[day] => 0
[monthnum] => 0
[year] => 0
[w] => 0
[category_name] =>
[tag] =>
[cat] =>
[tag_id] =>
[author] =>
[author_name] =>
[feed] =>
[tb] =>
[meta_value] =>
[preview] =>
[s] =>
[sentence] =>
[title] =>
[fields] =>
[menu_order] =>
[embed] =>
[category__in] => Array
(
)
[category__not_in] => Array
(
)
[category__and] => Array
(
)
[post__in] => Array
(
)
[post__not_in] => Array
(
)
[post_name__in] => Array
(
)
[tag__in] => Array
(
)
[tag__not_in] => Array
(
)
[tag__and] => Array
(
)
[tag_slug__in] => Array
(
)
[tag_slug__and] => Array
(
)
[post_parent__in] => Array
(
)
[post_parent__not_in] => Array
(
)
[author__in] => Array
(
)
[author__not_in] => Array
(
)
[search_columns] => Array
(
)
[ignore_sticky_posts] =>
[suppress_filters] =>
[cache_results] => 1
[update_post_term_cache] => 1
[update_menu_item_cache] =>
[lazy_load_term_meta] => 1
[update_post_meta_cache] => 1
[nopaging] =>
[comments_per_page] => 50
[no_found_rows] =>
)
[tax_query] => WP_Tax_Query Object
(
[queries] => Array
(
)
[relation] => AND
[table_aliases:protected] => Array
(
)
[queried_terms] => Array
(
)
[primary_table] => wp_posts
[primary_id_column] => ID
)
[meta_query] => WP_Meta_Query Object
(
[queries] => Array
(
[0] => Array
(
[key] => _ilsi_date
)
[relation] => OR
)
[relation] => AND
[meta_table] => wp_postmeta
[meta_id_column] => post_id
[primary_table] => wp_posts
[primary_id_column] => ID
[table_aliases:protected] => Array
(
[0] => wp_postmeta
)
[clauses:protected] => Array
(
[wp_postmeta] => Array
(
[key] => _ilsi_date
[compare] => =
[compare_key] => =
[alias] => wp_postmeta
[cast] => CHAR
)
)
[has_or_relation:protected] =>
)
[date_query] =>
[request] =>
SELECT SQL_CALC_FOUND_ROWS wp_posts.ID
FROM wp_posts INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
WHERE 1=1 AND (
wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
GROUP BY wp_posts.ID
ORDER BY wp_postmeta.meta_value DESC
LIMIT 72, 6
[posts] => Array
(
[0] => WP_Post Object
(
[ID] => 22941
[post_author] => 2
[post_date] => 2020-08-26 09:44:37
[post_date_gmt] => 2020-08-26 14:44:37
[post_content] =>
[post_title] => Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-the-environmental-risk-assessment-of-substances-of-unknown-or-variable-composition-complex-reaction-products-or-biological-materials-uvcbs
[to_ping] =>
[pinged] =>
[post_modified] => 2020-08-26 09:44:37
[post_modified_gmt] => 2020-08-26 14:44:37
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22941
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[1] => WP_Post Object
(
[ID] => 22866
[post_author] => 2
[post_date] => 2020-07-20 10:05:25
[post_date_gmt] => 2020-07-20 15:05:25
[post_content] =>
[post_title] => Approaches to Dose Finding in Neonates, Illustrating the Variability Between Neonatal Drug Development Programs
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => approaches-to-dose-finding-in-neonates-illustrating-the-variability-between-neonatal-drug-development-programs
[to_ping] =>
[pinged] =>
[post_modified] => 2020-07-20 10:05:25
[post_modified_gmt] => 2020-07-20 15:05:25
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22866
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[2] => WP_Post Object
(
[ID] => 22944
[post_author] => 2
[post_date] => 2020-08-27 11:52:12
[post_date_gmt] => 2020-08-27 16:52:12
[post_content] =>
[post_title] => Echocardiographic and Hemodynamic Indices of Myocardial Contractility Simultaneously Evaluated in Telemetered Beagle Dogs: A HESI-Sponsored Cross-Company Evaluation
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => echocardiographic-and-hemodynamic-indices-of-myocardial-contractility-simultaneously-evaluated-in-telemetered-beagle-dogs-a-hesi-sponsored-cross-company-evaluation
[to_ping] =>
[pinged] =>
[post_modified] => 2020-08-27 11:52:12
[post_modified_gmt] => 2020-08-27 16:52:12
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22944
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[3] => WP_Post Object
(
[ID] => 22826
[post_author] => 2
[post_date] => 2020-06-26 08:07:08
[post_date_gmt] => 2020-06-26 13:07:08
[post_content] =>
[post_title] => The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => the-gut-microbiome-and-xenobiotics-identifying-knowledge-gaps
[to_ping] =>
[pinged] =>
[post_modified] => 2020-06-26 08:07:08
[post_modified_gmt] => 2020-06-26 13:07:08
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22826
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[4] => WP_Post Object
(
[ID] => 22776
[post_author] => 2
[post_date] => 2020-06-04 08:39:05
[post_date_gmt] => 2020-06-04 13:39:05
[post_content] =>
[post_title] => PBPK Model Reporting Template for Chemical Risk Assessment Applications
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => pbpk-model-reporting-template-for-chemical-risk-assessment-applications
[to_ping] =>
[pinged] =>
[post_modified] => 2020-06-04 08:39:05
[post_modified_gmt] => 2020-06-04 13:39:05
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22776
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[5] => WP_Post Object
(
[ID] => 22760
[post_author] => 2
[post_date] => 2020-05-22 11:45:56
[post_date_gmt] => 2020-05-22 16:45:56
[post_content] =>
[post_title] => ‘All In’: A Pragmatic Framework for COVID‐19 Testing and Action on a Global Scale
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => all-in-a-pragmatic-framework-for-covid%e2%80%9019-testing-and-action-on-a-global-scale
[to_ping] =>
[pinged] =>
[post_modified] => 2020-05-22 11:45:56
[post_modified_gmt] => 2020-05-22 16:45:56
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22760
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
)
[post_count] => 6
[current_post] => -1
[before_loop] =>
[in_the_loop] =>
[post] => WP_Post Object
(
[ID] => 22941
[post_author] => 2
[post_date] => 2020-08-26 09:44:37
[post_date_gmt] => 2020-08-26 14:44:37
[post_content] =>
[post_title] => Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)
[post_excerpt] =>
[post_status] => publish
[comment_status] => closed
[ping_status] => closed
[post_password] =>
[post_name] => improving-the-environmental-risk-assessment-of-substances-of-unknown-or-variable-composition-complex-reaction-products-or-biological-materials-uvcbs
[to_ping] =>
[pinged] =>
[post_modified] => 2020-08-26 09:44:37
[post_modified_gmt] => 2020-08-26 14:44:37
[post_content_filtered] =>
[post_parent] => 0
[guid] => https://hesiglobal.org/?post_type=publication&p=22941
[menu_order] => 0
[post_type] => publication
[post_mime_type] =>
[comment_count] => 0
[filter] => raw
)
[comment_count] => 0
[current_comment] => -1
[found_posts] => 479
[max_num_pages] => 80
[max_num_comment_pages] => 0
[is_single] =>
[is_preview] =>
[is_page] =>
[is_archive] =>
[is_date] =>
[is_year] =>
[is_month] =>
[is_day] =>
[is_time] =>
[is_author] =>
[is_category] =>
[is_tag] =>
[is_tax] =>
[is_search] =>
[is_feed] =>
[is_comment_feed] =>
[is_trackback] =>
[is_home] => 1
[is_privacy_policy] =>
[is_404] =>
[is_embed] =>
[is_paged] => 1
[is_admin] =>
[is_attachment] =>
[is_singular] =>
[is_robots] =>
[is_favicon] =>
[is_posts_page] =>
[is_post_type_archive] =>
[query_vars_hash:WP_Query:private] => ab67a788d2ba3a19ba6bbcad2081b10f
[query_vars_changed:WP_Query:private] =>
[thumbnails_cached] =>
[allow_query_attachment_by_filename:protected] =>
[stopwords:WP_Query:private] =>
[compat_fields:WP_Query:private] => Array
(
[0] => query_vars_hash
[1] => query_vars_changed
)
[compat_methods:WP_Query:private] => Array
(
[0] => init_query_flags
[1] => parse_tax_query
)
)