Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Derivation of Algal Acute to Chronic Ratios for Use in Chemical Toxicity Extrapolations

Chemosphere, 2021

Brill JL, Belanger SE, Barron MG, Beasley A, Connors KA, Embry M, ...

Algal toxicity studies are required by regulatory agencies for a variety of purposes including classification and labeling and environmental risk assessment of chemicals. Algae are also frequently the most sensitive taxonomic group tested. Acute to chronic ratios (ACRs) have been challenging to derive for algal species ...

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Urinary miRNA Biomarkers of Drug-Induced Kidney Injury and Their Site Specificity Within the Nephron

Toxicological Sciences, 2020

Chorley BN, Ellinger-Ziegelbauer H, Tackett M, Simutis FJ, ...

Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury in the loop of Henle and the collecting duct (CD). A cross-laboratory program to identify and characterize urinary microRNA (miRNA) patterns ...

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Health Disparities, COVID-19, and Owning Our Share

Toxicological Sciences, 2020

Pettit SD

The COVID-19 pandemic has left many frightened, saddened, and angered at its impact on our lives and the world around us. The disease has laid bare failures to protect our citizens generally but our vulnerable and underserved most of all. Growing evidence reveals that minority and low-income populations are experiencing ...

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Can We Panelize Seizure?

Toxicological Sciences, 2020

Roberts R, Authier S, Mellon D, Morton M, Suzuki I, Tjalkens RB, ...

Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs ...

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Repolarization Studies Using Human Stem Cell-Derived Cardiomyocytes: Validation Studies and Best Practice Recommendations

Regulatory Toxicology and Pharmacology, 2020

Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, ...
  • HESI - Health and Environmental Sciences Institute

Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the ability of hSC-CMs to detect drug-induced delayed ...

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Development of the First Reference Antibody Panel for Qualification and Validation of Cytokine Release Assay Platforms: Report of an International Collaborative Study

Cytokine, 2020

Vessillier S, Fort M, O'Donnell L, Hinton H, Nadwodny K, ...

Author links open overlay Immunomodulatory therapeutics such as monoclonal antibodies (mAb) carry an inherent risk of undesired immune reactions. One such risk is cytokine release syndrome (CRS), a rapid systemic inflammatory response characterized by the secretion of pro-inflammatory cytokines from immune cells. It is ...

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