November 14, 2022
Denver, Colorado, USA
Don’t miss the overview of CT-TRACS’ Advanced Sequencing project as well at a talk by the GTTC on the HESI Nitrosamine Subgroup at the upcoming American College of Toxicology Annual Meeting.
March 22, 2018 – March 23, 2018
Potsdam, Germany
Applied genetic toxicology is undergoing a major paradigm shift towards changing the strategies employed for assessment of chemically-induced genomic damage, evaluation methods of the mechanisms by which that damage translates into adverse effects, and the quantitative methods used to interpret dose-response data. This ...
September 9, 2023 – September 13, 2023
Chicago, IL, USA
Several HESI programs will be featured throughout the meeting.
May 31, 2023 – June 1, 2023
Webcast, Washington DC
This workshop will engage invited stakeholders and key opinion leaders with expertise in the assessment of nitrosamines (NA), including Nitrosamine Drug Substance-related Impurities (NDSRI) detection and evaluation in order to achieve the following:
April 10, 2024 – April 12, 2024
University of Delaware, Newark, DE
Members of the HESI Genetic Toxicology Technical Committee will be presenting.
May 7, 2023 – May 9, 2023
GTTC, Annual Meeting
Save the Date! The GTTC will hold their Annual Meeting from May 7-9th, 2023.
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Mirjam Luitjen, RIVM
Kerry Dearfield, Former USDA
Veronique Thybaud, Sanofi & Nicholas Ball, DOW
Roland Frötschl, BfArM, Germany
Stefan Pfuhler, Procter & Gamble
Azeddine Elhajouji, Novartis
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George Johnson, Swansea University
Background and Objectives
Applied genetic toxicology is undergoing a major paradigm shift towards changing the strategies employed for assessment of chemically-induced genomic damage, evaluation methods of the mechanisms by which that damage translates into adverse effects, and the quantitative methods used to interpret dose-response data. This shift entails a movement away from simple dichotomous evaluations of genotoxicity (i.e., yes/no), that only supports identification of potential carcinogens, and towards a greater understanding of the diversity of adverse outcomes related to genomic damage, of the multitude of mechanisms (or modes of action) underscoring genomic damage, and the ability to determine point of departure metrics for human health risk assessment and regulatory decision making. Moreover, advanced technologies to investigate genotoxic mechanisms and to analyze dose-response functions are being developed and incorporated into assessments of genomic damage.
This workshop was organized by the HESI Genetic Toxicology Technical Committee (GTTC). The HESI GTTC brings together an international cohort of genetic toxicologists from industry, academia, and government to address issues related to all aspects of genetic toxicity assessment. These aspects include the development and validation of assessment approaches, technologies and strategies for mode-of-action determination, and approaches for data interpretation. The GTTC is comprised of experts in the fields of genetic and general toxicology, risk assessment, and computational biology. The workshop will examine a new generation of testing strategy for assessment of genomic damage, new approaches and technologies for mode-of-action determination and interpretation, and recent developments in quantitative interpretation of genetic toxicity dose-response data.
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