Note: As of 2022, the former Animal Alternatives in ERA and Bioaccumulation Committees have merged to form the Next Generation ERA Committee
To develop, refine, and communicate the scientific tools and approaches needed to support ecological risk assessment around the globe, with a focus on alternative, non-animal testing methods.
Building from previous committee work, a new scoping group will be formed 2Q 2022 to explore recent challenges and opportunities related to alternatives for chronic fish tests (e.g., OECD TG 210).
This working group is focused on understanding the processes that impact the behavior of contaminants within an organism in order to refine ecological risk assessment. Though much of the initial work was focused specifically on bioaccumulation metrics, the group has expanded to consider how toxicokinetics can help inform interpretation of toxicity data, study design, cross-species extrapolations, and species sensitivity. The group has 3 sub-groups that are each focusing on various taxa important for ecological risk assessment: birds, invertebrates, and fish.
This team, a collaboration between HESI and NC3Rs, is focused on assessing available in vitro/in silico methods (new approach methodologies [NAMs]) to evaluate chemicals that may act via an endocrine pathway in fish and amphibians. Within this effort, several sub-groups focus on related supporting topics:
This team is working to engage with various stakeholders about current effluent testing approaches and needs within North America, to identify the opportunities and limitations related to alternative methods. Ongoing work is focused on the development of informational webinars and information sharing across stakeholders to identify suitable next steps.
This group is tasked with developing a strategy to update and augment the EnviroTox database (https://envirotoxdatabase.org) and refine and further develop applicable tools. Case studies to illustrate the use and application of the database and tools are ongoing.
Michelle Embry received her PhD in Toxicology in 2004 and her BS in Biology and Environmental Science and Policy in 1998 from Duke University. She is currently the Deputy Director of Environmental Science at HESI, where she provides leadership, technical direction, and guidance to varied, multi-stakeholder, collaborative committees on topics related to risk assessment and environmental protection worldwide.
Prior to joining HESI in 2006, Dr. Embry worked as an Ecological Risk Assessor at the US EPA’s Office of Pesticide Programs. She has expertise in both human health and ecotoxicology, with an emphasis on integrated approaches and alternative methods. Her current project portfolio includes the Animal Alternatives in Environmental Risk Assessment Committee and the Development of Methods for a Tiered Approach to Assess Bioaccumulation of Chemicals Committee, two of HESI’s projects aimed at improving ecological risk assessment. Dr. Embry’s work also includes the Risk Assessment in the 21st Century (RISK21) Committee, which developed a scientific, transparent, and efficient approach for human health risk assessment, including a web-based tool that has led to outreach and training activities on risk assessment approaches worldwide. In addition, she works with HESI staff and partners on project development related to chemical risk assessment issues.
Dr. Embry is an elected member of the SETAC North America Board of Directors (2014 to present), chair of the SETAC Global Partners Advisory Committee, and a member of the SETAC Bioaccumulation and Animal Alternatives Advisory Group Steering Teams. She is a full member of the Society of Toxicology (SOT) and a member of the SOT Risk Assessment and Mixtures Specialty Sections. She was a member of the ECETOC Task Force on Information to be Considered in a Weight-of-Evidence-Based PBT/vPvB Assessment of Chemicals (Annex XIII of REACH) in 2013 to 2014 and was a steering team member of the SETAC Adverse Outcome Pathway (AOP) Pellston Workshop (Spring 2017). Dr. Embry is also one of the founding partners on the “eco data hub” initiative, started in Fall 2016.
Sandrine Deglin joined HESI in 2018 as a Scientific Program Manager. Prior to joining HESI, she worked with the Environmental Public Health Program at the State of Alaska Division of Public Health for four years, where she managed the program for nearly two years. Prior to that time, Dr. Deglin spent seven years as a consultant in the Toxicology and Mechanistic Biology Group of Exponent, Inc.
Dr. Deglin holds a PhD in Applied Chemistry and an MS in Environmental Sciences and Engineering from the Colorado School of Mines. While studying in France, she also received a MS in Chemistry and a postgraduate degree in Public Health. Dr. Deglin is interested in all aspects of environmental health, including chemical fate and transport, toxicology, epidemiology, risk assessment, food safety and food security, and risk communication. She is currently involved in the HESI Bioaccumulation, Environmental Epidemiology, RISK21, UVCB, and Transforming the Evaluation of Agrochemicals (TEA) Committees.
Connie Mitchell is a Senior Scientific Program Manager at HESI. Prior to joining HESI in early 2020, she was an ORISE Fellow at the US Environmental Protection Agency working on chemical prioritization under the Toxic Substances Control Act. She completed her graduate studies in Environmental Toxicology at the University of California Riverside. There she investigated flame retardant-induced developmental toxicity. As a Senior Scientific Program Manager, she provides scientific, strategic, and management support to collaborative scientific committees involving academic, government, nonprofit, and private sector scientists. She manages the Emerging Systems Toxicology for Assessment of Risk (eSTAR) Committee, Next Generation Ecological Risk Assessment Committee (Eco-Risk), and the Botanical Safety Consortium (BSC).
Dr. Julie Krzykwa holds a PhD in Biology from Texas Christian University under the guidance of long-time HESI collaborator and advocate, Dr. Marlo Jeffries. Dr. Krzykwa’s dissertation research on fish embryo acute toxicity test (OECD 236) was awarded a SETAC/Procter & Gamble Fellowship for Doctoral Research in Environmental Science and received a STARS and Ida M. Green Fellowship awards from TCU. She brings post-graduate experience as a contractor to the USEPA working on aquatic toxicity testing methods and as Study Director (ecotox) for Smithers contract laboratory. Dr. Krzykwa will work on the Next Generation EcoRisk Project, UVCB Committee, and the Botanical Safety Consortium.
Chemosphere, 2021
Algal toxicity studies are required by regulatory agencies for a variety of purposes including classification and labeling and environmental risk assessment of chemicals. Algae are also frequently the most sensitive taxonomic group tested. Acute to chronic ratios (ACRs) have been challenging to derive for algal species ...
No results.
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