UVCBs and Multi-Constituent Substances (MCS) Committee

Mission Statement

The mission of the committee is to develop a tiered approach for the ecological risk assessment of substances of Unknown or Variable composition, Complex reaction products or Biological materials (UVCBs) and Multi-Constituents Substances (MCS).

Call for Stakeholders

Would you like to help crack the problem of UVCB/ Multi-Constituent Substances (MCS) risk assessment?

HESI’s UVCB/MCS Committee is currently developing an exposure-based, tiered ecological risk assessment approach for these substances?

We are presently looking for stakeholders of all sectors to join us in fulfilling this challenging mission.

For details contact Sandrine Deglin (sdeglin@hesiglobal.org)

Working Groups

  • Tier 0 Database Development

    A small sub-group was created to discuss the creation of a database of exposure and characterization information that would be readily available to risk assessors. This information would be crude, Tier 0 information, and would be used for an initial screening of UVCB substances.

  • UVCB Complexity Evaluation

    The group worked on the development of a UVCB complexity evaluation scheme that, once finalized, will be integrated to the risk assessment framework to help screen substances early into their assessment. This framework would rely on Tier 0 data.

  • Workshop Organization

    This workgroup will focus on the organization of a face-to-face workshop in the early fall of 2023. This workshop will be open to participants outside of HESI’s UVCB committee, and will be an opportunity to share knowledge in the UVCB risk assessment space.

HESI Staff

Leadership Team

  • Marc Fernandez, PhD

    Environment and Climate Change Canada

Committee Publications

Filter

Improving the Environmental Risk Assessment of Substances of Unknown or Variable Composition, Complex Reaction Products, or Biological Materials (UVCBs)

Environmental Toxicology and Chemistry, 2020

Salvito D, Fernandez M, Jenner K, Lyon DY, de Knecht J, Mayer P, ...
  • HESI - Health and Environmental Sciences Institute

Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) pose unique risk assessment challenges to regulators and to product registrants. These substances can contain many constituents, sometimes partially unknown and/or variable, depending on fluctuations in their ...

Read more

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Events

Filter

SETAC North America

October 20, 2024 – October 24, 2024

Fort Worth, Texas, USA

The UVCBs and Multi-Constituent Substances (MCS) Committee and the Next Generation Ecological Risk Assessment Committee will be attending SETAC North America in Fort Worth, Texas. Connect with us!

Read more

SETAC Europe 2024

May 5, 2024 – May 9, 2024

Seville, Spain

The NextGen EcoRisk Committee will be presenting at SETAC Europe.

Read more

HESI UVCB Workshop

September 18, 2023 – September 19, 2023

Reykjavik, Iceland

HESI's UVCB Committee hosts an interactive 2-day workshop exploring the complexities of UVCBs for testing and risk assessment.

Read more

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