Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Rehm S, Solleveld HA, Portelli ST, Wier PJ
- HESI - Health and Environmental Sciences Institute
Idoxifene is a selective estrogen receptor modulator similar to tamoxifen but is no longer in pharmaceutical development due to adverse genitourinary effects in the clinic.
Birth Defects Research, 2024
Green et al.
Output from the HESI DART workshop entitled, “Interpretation of Developmental and Reproductive Toxicology in Regulatory Contexts and Frameworks” has been published. The purpose of the workshop was to capture key consensus approaches used to assess DART risks associated with chemical and pharmaceutical product exposure ...
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2011
Beyer BK, Chernoff N, Danielsson BR, Davis‐Bruno K, Harrouk W, ...
- HESI - Health and Environmental Sciences Institute
Workshops on maternal toxicity were held at the annual Society of Toxicology, Teratology Society, and European Teratology Society meetings in 2009.
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2014
Daston GP, Beyer BK, Carney EW, Chapin RE, Friedman JM, ...
- HESI - Health and Environmental Sciences Institute
Validation of alternative assays requires comparison of the responses to toxicants in the alternative assay with in vivo responses.
Reproductive Toxicology, 2015
Thompson KE, Newcomb DL, Moffat GJ, Zalikowski J, Chellman GJ, ...
- HESI - Health and Environmental Sciences Institute
Given concern about potential embryo-fetal harm following seminal exposure to drugs with teratogenic potential, pharmaceutical companies use theoretical calculations to estimate seminal concentrations, maternal exposure, and distribution across the placenta to the embryo-fetal compartment for risk ...
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2007
Li S, Davis B
- HESI - Health and Environmental Sciences Institute
Interpreting histopathology of the female rodent reproductive tract can be challenging in toxicity studies.
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