Top dose selection for repeated dose animal studies has generally focused on identification of apical endpoints, use of the limit dose, or determination of a maximum tolerated dose (MTD). The intent is to optimize the ability of toxicity tests performed in a small number of animals to detect effects for hazard identification. An ...
Opportunities and Challenges Related to Saturation of Toxicokinetic Processes: Implications for Risk Assessment
Regulatory Toxicology and Pharmacology, 2021