The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.
This review is part of a multi-sector collaborative research effort coordinated by HESI Development and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population.
Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.
The HESI Sustainable Alternatives Committee completed a study to understand potential tradeoffs concerning final product design and redesign decisions using a set of six factors affecting product design: business strategy, economic considerations, functionality and performance, health/environmental endpoints, public perception, and regulatory factors. The results are published here.
HESI’s Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC’s Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an effluent evaluation “toolbox.”