Peer-Reviewed Publications

All Publications

Analyzing chemical substitution decisions among chemical and product manufacturers

The HESI Sustainable Alternatives Committee completed a study to understand potential tradeoffs concerning final product design and redesign decisions using a set of six factors affecting product design: business strategy, economic considerations, functionality and performance, health/environmental endpoints, public perception, and regulatory factors. The results are published here.

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An International Perspective on the Tools and Concepts for Effluent Toxicity Assessments in the Context of Animal Alternatives: Reduction in Vertebrate Use

HESI’s Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC’s Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an effluent evaluation “toolbox.”

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Practical advice for selecting or determining trophic magnification factors for application under the European Union Water Framework Directive

The HESI Bioaccumulation Committee has published practical advice for selecting or determining TMFs within the context of the European Union’s Water Framework Directive. A decision tree based on a series of quality attributes for TMF is provided, along with several illustrative examples.

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International Multisite Study of Human Induced Pluripotent Stem Cell Derived Cardiomyocytes for Drug Proarrhythmic Potential Assessment

The HESI Cardiac Safety Myocyte Subteam completed a validation study with the CiPA 28, two commercial human cardiomyocyte cell lines, 5 devices across 10 sites. The results are published here.

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Protease resistance of food proteins: a mixed picture for predicting allergenicity but a useful tool for assessing exposure

Susceptibility to pepsin digestion of candidate transgene products is regarded an important parameter in the weight-of-evidence approach for allergenicity risk assessment of genetically modified crops. It has been argued that protocols used for this assessment should better reflect physiological conditions encountered in representative food consumption scenarios.

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