Peer-Reviewed Publications

All Publications

Creation of a Curated Aquatic Toxicology Database: EnviroTox

The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.

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Physiology of the neonatal gastrointestinal system relevant to the disposition of orally administered medications

This review is part of a multi-sector collaborative research effort coordinated by HESI Development and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population.

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A Proof-of-Concept Evaluation of JTPc and Tp-Tec as Proarrhythmia Biomarkers in Preclinical Species: A Retrospective Analysis by an HESI-Sponsored Consortium

Results from this limited retrospective electrocardiogram analysis suggest that JTpca and Tpeca may discriminate selective IKr blockers and multichannel blockers and could be considered in the context of an integrated comprehensive proarrhythmic risk assessment.

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Analyzing chemical substitution decisions among chemical and product manufacturers

The HESI Sustainable Alternatives Committee completed a study to understand potential tradeoffs concerning final product design and redesign decisions using a set of six factors affecting product design: business strategy, economic considerations, functionality and performance, health/environmental endpoints, public perception, and regulatory factors. The results are published here.

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An International Perspective on the Tools and Concepts for Effluent Toxicity Assessments in the Context of Animal Alternatives: Reduction in Vertebrate Use

HESI’s Animal Alternatives in ERA Committee published tools and concepts for effluent toxicity assessment in an issue of SETAC’s Environmental Toxicology and Chemistry. The publication discusses a suite of strategies that can be used in a weight of evidence approach to reduce reliance on in vivo fish tests as part of an effluent evaluation “toolbox.”

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