The Amphibian Metamorphosis Assay (AMA) is used to identify substances that potentially interfere with the normal function of the hypothalamic-pituitary-thyroid (HPT) axis. The current investigation reviewed 51 AMA experiments conducted at 7 different laboratories in Europe and North America. Diagnostic approaches to evaluating the histopathology endpoint are discussed, and several recommendations are proposed for the refinement of core diagnostic criteria assessment.
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An examination of historical control histopathology metadata from 51 Amphibian Metamorphosis Assays. Wolf JC, Bejarano AC, Fort DJ and Wheeler JR. Critical Reviews in Toxicology. DOI:10.1080/10408444.2021.1997910
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