An examination of historical control histopathology metadata from 51 Amphibian Metamorphosis Assays

The Amphibian Metamorphosis Assay (AMA) is used to identify substances that potentially interfere with the normal function of the hypothalamic-pituitary-thyroid (HPT) axis. The current investigation reviewed 51 AMA experiments conducted at 7 different laboratories in Europe and North America. Diagnostic approaches to evaluating the histopathology endpoint are discussed, and several recommendations are proposed for the refinement of core diagnostic criteria assessment.

Read the full articles here:

An examination of historical control histopathology metadata from 51 Amphibian Metamorphosis Assays. Wolf JC, Bejarano AC, Fort DJ and Wheeler JR. Critical Reviews in Toxicology. DOI:10.1080/10408444.2021.1997910

Learn more about the HESI Next Generation Ecological Risk Assessment Committee