In this review, we discuss promising applications, challenges, limitations, and key data initiatives needed to enable regulatory testing and adoption of ecNGS – including for advancing safety assessment, augmenting weight-of-evidence for mutagenicity and carcinogenicity mechanisms, identifying early biomarkers of cancer risk, and managing human health risk from chemical exposures.
Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment. Marchetti et al. (September 2023) Mutation Research/Reviews in Mutation Research. https://doi.org/10.1016/j.mrrev.2023.108466
Learn more about the HESI Genetic Toxicology Technical Committee