AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations

HESI's Genetic Toxicology Technical Committee (GTTC) aims to enhance the use of mechanistic information in genotoxicity assessment by building empirical support for the relationship between molecular initiating events and regulatory endpoints in genetic toxicology with the development of several adverse outcome pathways (AOPs): oxidative stress, tubulin binding, topoisomerase II and aurora kinase. The GTTC’s first adverse outcome pathway (AOP) describing modes of actions leading to potentially heritable genomic damage was recently published in Environmental and Molecular Mutagenesis. This AOP focused on oxidative DNA damage and resulting mutations and chromosomal aberrations. This AOP is currently included in the OECD workplan and is awaiting approval and endorsement. For additional information, please contact Connie Chen (cchen@hesiglobal.org).

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AOP report: Development of an adverse outcome pathway for oxidative DNA damage leading to mutations and chromosomal aberrations. Eunnara Cho, Ashley Allemang, Marc Audebert, Vinita Chauhan, Stephen Dertinger, Giel Hendriks, Mirjam Luijten, Francesco Marchetti, Sheroy Minocherhomji, Stefan Pfuhler, Daniel J. Roberts, Kristina Trenz, Carole L. Yauk. Environmental and Molecular Mutagenesis. 21 March 2022.

Click to learn more about HESI's Genetic Toxicology Technical Committee (GTTC)

UPDATE: This article was selected as the June 2022 Editor’s Choice Article by Environmental and Molecular Mutagenesis.