Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.

J Pharmacol Toxicol Methods., 2018

Chiang AY, Guth BD, Pugsley MK, Foley CM, Doyle JM, Engwall MJ, ...
  • HESI - Health and Environmental Sciences Institute

The HESI Cardiac Safety Committee designed and conducted studies to evaluate inherent variability in telemetry implanted dogs. This paper discusses details of the statistical methods used to evaluate a primary endpoint for measuring blood pressure changes.

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The Gut Microbiome and Xenobiotics: Identifying Knowledge Gaps

Toxicological Sciences, 2020

Sutherland VL, McQueen CA, Mendrick D, Gulezian D, Cerniglia C, ...
  • HESI - Health and Environmental Sciences Institute

There is an increasing awareness that the gut microbiome plays a critical role in human health and disease, but mechanistic insights are often lacking. In June 2018, HESI held a workshop, “The Gut Microbiome: Markers of Human Health, Drug Efficacy and Xenobiotic Toxicity” to identify data gaps in determining how gut ...

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The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis

Journal of Pharmacological and Toxicological Methods, 2023

Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, ...

Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies.

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