The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis
- Publication Date :
- Publication Type : Journal Article
- Author(s) : Emmanuel Boulay, Loïs S. Miraucourt, Michael K. Pugsley, Matthew M. Abernathy, Ray Chui, Jill Dalton, Marjorie Demers, Noel Dybdal, Elissa Gazaille, Andrea Greiter-Wilke, Peter Hoffmann, Hai Huang, Carrie LaDuke, Kevin Norton, Jennifer B. Pierson, Isabelle Reeves, Brian Roche, Eric I. Rossman, Albert E. Schultze, Hai-Ming Tang, Simon Authier
- Journal Name : Journal of Pharmacological and Toxicological Methods
The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis was recently accepted for publication in the Journal of Pharmacological and Toxicological Methods, https://doi.org/10.1016/j.vascn.2023.107266. Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies. Understanding this background level of spontaneous arrhythmias is important for interpretation of results when evaluating drugs in a safety study. Additionally, authors compared findings from non-implanted telemetered animals and found no significant differences in the implanted animals.
Learn more about the HESI Cardiac Safety Committee or contact Jennifer Pierson (jpierson@hesiglobal.org) for more information.