The incidence of spontaneous arrhythmias in telemetered beagle dogs, Göttingen Minipigs and Cynomolgus non-human primates: A HESI consortium retrospective analysis was recently accepted for publication in the Journal of Pharmacological and Toxicological Methods, https://doi.org/10.1016/j.vascn.2023.107266. Members of the HESI Cardiac Safety Committee pooled retrospective data to explore the incidence of spontaneous arrhythmias and effect of telemetry implants in species typically used in safety pharmacology studies. Understanding this background level of spontaneous arrhythmias is important for interpretation of results when evaluating drugs in a safety study. Additionally, authors compared findings from non-implanted telemetered animals and found no significant differences in the implanted animals.
Learn more about the HESI Cardiac Safety Committee or contact Jennifer Pierson (firstname.lastname@example.org) for more information.
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