Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Symposium Summary: Children’s Health Risk—What’s So Special About the Developing Immune System?

Toxicology and Applied Pharmacology, 2004

Holsapple MP, Paustenbach DJ, Charnley G, West LJ, Luster MI, ...
  • HESI - Health and Environmental Sciences Institute

In recent years, there has been increasing regulatory pressure to protect the health of children, with the basic tenet being that children differ significantly from adults in their biological or physiological responses to chemical exposures.

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TCDD-Mediated Suppression of the In Vitro Anti-Sheep Erythrocyte IgM Antibody Forming Cell Response Is Reversed by Interferon-Gamma

Toxicological Sciences, 2009

North CM, Kim BS, Snyder N, Crawford RB, Holsapple MP, ...
  • HESI - Health and Environmental Sciences Institute

Suppression of humoral immune responses by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) has been well established to require the aryl hydrocarbon receptor; however, the downstream mechanisms for this immunotoxic response remain poorly understood.

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TGx-DDI, A Transcriptomic Biomarker for Genotoxicity Hazard Assessment of Pharmaceuticals and Environmental Chemicals

Frontiers in Big Data, 2019

Li HH, Yauk C, Chen R, Hyduke DR, Williams A, Frötschl R, ...

Genotoxicity testing is an essential component of the safety assessment paradigm required by regulatory agencies world-wide for analysis of drug candidates, and environmental and industrial chemicals. Current genotoxicity testing batteries feature a high incidence of irrelevant positive findings – particularly for in ...

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