Regulatory Toxicology and Pharmacology, 2020
Gintant G, Kaushik EP, Feaster T, Stoelzle-Feix S, Kanda Y, ...
- HESI - Health and Environmental Sciences Institute
Human stem cell-derived cardiomyocytes (hSC-CMs) hold great promise as in vitro models to study the electrophysiological effects of novel drug candidates on human ventricular repolarization. Two recent large validation studies have demonstrated the ability of hSC-CMs to detect drug-induced delayed ...
Toxicological Sciences, 2020
Roberts R, Authier S, Mellon D, Morton M, Suzuki I, Tjalkens RB, ...
Seizure liability remains a significant cause of attrition in drug discovery and development, leading to loss of competitiveness, delays and increased costs. Current detection methods rely on observations made in in vivo studies intended to support clinical trials, such as tremors or other abnormal movements. These signs ...
Toxicological Sciences, 2020
Pettit SD
The COVID-19 pandemic has left many frightened, saddened, and angered at its impact on our lives and the world around us. The disease has laid bare failures to protect our citizens generally but our vulnerable and underserved most of all. Growing evidence reveals that minority and low-income populations are experiencing ...
Toxicological Sciences, 2020
Chorley BN, Ellinger-Ziegelbauer H, Tackett M, Simutis FJ, ...
Drug-induced kidney injury (DIKI) is a major concern in both drug development and clinical practice. There is an unmet need for biomarkers of glomerular damage and more distal renal injury in the loop of Henle and the collecting duct (CD). A cross-laboratory program to identify and characterize urinary microRNA (miRNA) patterns ...
Journal of Pharmacological and Toxicological Methods, 2021
Pugsley MK, Brooks MB, Fishman CE, Katavolos P, Chiang AY, ...
The study (Pugsley et al., 2021. Journal of Pharmacological and Toxicological Methods) focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats, including biomarkers to detect early signs of hypercoagulability and vascular injury in the absence of overt thrombosis. Results ...
Chemosphere, 2021
Brill JL, Belanger SE, Barron MG, Beasley A, Connors KA, Embry M, ...
Algal toxicity studies are required by regulatory agencies for a variety of purposes including classification and labeling and environmental risk assessment of chemicals. Algae are also frequently the most sensitive taxonomic group tested. Acute to chronic ratios (ACRs) have been challenging to derive for algal species ...