Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy
- Publication Date :
- Publication Type : Journal Article
- Author(s) : Pugsley MK, Brooks MB, Fishman CE, Katavolos P, Chiang AY, Parish ST, Schultze AE, & Pierson JB
- Journal Name : Journal of Pharmacological and Toxicological Methods
This HESI Cardiac Safety Committee article titled “Use of the ZDF Rat to Model Dietary Fat Induced Hypercoagulability is Limited by Progressive and Fatal Nephropathy” has been linked to the United Nations Sustainable Development Goal 3: Ensure healthy lives and promote well-being for all at all ages. HESI is proud to be recognized for their contribution to building science for a safer, more sustainable world through cross-sector global collaborative initiatives.
The study (Pugsley et al., 2021., Journal of Pharmacological and Toxicological Methods) focused on the effects of high versus low dietary fat on the development of Type 2 diabetes in obese male ZDF rats, including biomarkers to detect early signs of hypercoagulability and vascular injury in the absence of overt thrombosis. Results showed that the ZDF rat at the age, sex and weight used in this study is highly sensitive to dietary fat content that can exacerbate prothrombotic, metabolic and renal disturbances and increase mortality.
Full text online: https://www.sciencedirect.com/science/article/pii/S1056871920302641?via%3Dihub