Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Assessing drug-induced long QT and proarrhythmic risk using human stem cell-derived cardiomyocytes in a Ca2+ imaging assay: Evaluation of 28 CiPA compounds at three test sites

Toxicological Sciences, 2019

Hua Rong Lu, Haoyu Zeng, Ralf Kettenhofen, Liang Guo, ...
  • HESI - Health and Environmental Sciences Institute

A consortium, multi-site approach to testing in vitro assay technology for prediction of drug-induced TdP. The authors sought to test calcium transient assays using the CiPA 28 drugs.

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A Method for Sampling Rat Cerebrospinal Fluid with Minimal Blood Contamination: A Critical Tool for Biomarker Studies

Neuromethods, 2019

He Z, Panos J, Raymick J, Konak T, Cui L, Miller DB, ...

Sampling and analysis of cerebrospinal fluid (CSF) is a common clinical practice used in the diagnosis, treatment, and prevention of neurological diseases. A similar interest is the sampling of CSF from rats to bridge the gap between bench-to-bedside work and to foster the development of new CSF biomarkers for clinical use. Here, ...

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Mode of Action (MOA) Classifications in the EnviroTox Database: Development and Implementation of a Consensus MOA Classification

Environmental Toxicology and Chemistry, 2019

Kienzler A, Connors KA, Bonnell M, Barron MG, Beasley A, ...

Multiple modes of action (MOA) frameworks have been developed in aquatic ecotoxicology, mainly based on fish toxicity. These frameworks provide information on a key determinant of chemical toxicity, but the MOA categories and level of specificity remain unique to each of the classification schemes. This study aimed to develop a ...

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms

Frontiers in Pharmacology, 2019

Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, Gintant G, ...
  • HESI - Health and Environmental Sciences Institute

Drug-induced effects on cardiac contractility can be assessed through the measurement of the maximal rate of pressure increase in the left ventricle (LVdP/dtmax) in conscious animals, and such studies are often conducted at the late stage of preclinical drug development. Detection of such effects earlier in drug research using ...

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Stakeholder Perspectives on Addressing Adverse Events from Adjuvant Cancer Therapy: A Qualitative Study

Cancer, 2019

Syril D. Pettit, Pamela Silberman, Kristen Hassmiller Lich, ...
  • HESI - Health and Environmental Sciences Institute

With increasing survival rates, a growing population of patients with cancer have received or will receive adjuvant therapy to prevent cancer recurrences. Patients and caregivers will confront the complexities of balancing the preventative benefits of adjuvant therapy with possible near‐term or long‐term adverse ...

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Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes

Frontiers in Pharmacology, 2019

Ribeiro A, Guth BD, Engwall M, Eldridge S, Foley CM, Guo L, ...

Contractility of the myocardium engines the pumping function of the heart and is enabled by the collective contractile activity of its muscle cells: cardiomyocytes. The effects of drugs on the contractility of human cardiomyocytes in vitro can provide mechanistic insight that can support the prediction of clinical cardiac drug ...

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