Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Creation of a Curated Aquatic Toxicology Database: EnviroTox

Environmental Toxicology and Chemistry, 2019

Connors KA, Beasley A, Barron MG, Belanger SE, Bonnell M, ...

The HESI Animal Alternatives in Environmental Risk Assessment Committee completed the development of a large, diverse environmental database for the creation of an ecological threshold of toxicological concern (ecoTTC) tool.

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Physiology of the Neonatal Gastrointestinal System Relevant to the Disposition of Orally Administered Medications

Drug Metabolism and Disposition, 2019

Neal-Kluever A, Fisher J, Grylack L, Kakiuchi-Kiyota S, ...

This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et ...

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A Comparison of Transgenic Rodent Mutation and In Vivo Comet Assay Responses for 91 Chemicals

Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2019

Kirkland D, Levy DD, LeBaron MJ, Aardema MJ, Beevers C, Bhalli J, ...

Whilst the TGR and comet assays are available for measuring genotoxic effects in multiple rodent tissues, there has been no systematic comparison of their performance in detecting genotoxicity per se. A working group of the Genetic Toxicology Technical Committee (GTTC), part of the Health and Environmental Sciences Institute ...

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Improving Attribution of Adverse Events in Oncology Clinical Trials

Cancer Treatment Reviews, 2019

George GC, Barata PC, Campbell A, Chen A, Cortes JE, Hyman DM, ...
  • HESI - Health and Environmental Sciences Institute

Attribution of adverse events (AEs) is critical to oncology drug development and the regulatory process. However, processes for determining the causality of AEs are often sub-optimal, unreliable, and inefficient. Thus, a toxicity-attribution workshop was conducted in Silver Spring, MD to develop guidance for improving ...

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Health and Environmental Sciences Institute (HESI)

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