Analysis of Historical Negative Control Group Data from the In Vitro Micronucleus Assay Using Human Lymphocytes

The HESI Genetic Toxicology (GTTC) Committee Data Interpretation Workgroup initiated a project to collect and collate sets of data from established and experienced laboratories into a standardized database. This analysis and publication are intended to provide high quality negative control data from genotoxicity tests carried out under OECD guidelines. This group has previously reported on the negative control data from a set of in vitro micronuclei studies from a series of experienced laboratories using TK6 cells; this paper also provides additional background to the GTTC Data Interpretation project.

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