Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.

J Pharmacol Toxicol Methods., 2018

Chiang AY, Guth BD, Pugsley MK, Foley CM, Doyle JM, Engwall MJ, ...
  • HESI - Health and Environmental Sciences Institute

The HESI Cardiac Safety Committee designed and conducted studies to evaluate inherent variability in telemetry implanted dogs. This paper discusses details of the statistical methods used to evaluate a primary endpoint for measuring blood pressure changes.

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Simulation of Mouse and Rat Spermatogenesis to Inform Genotoxicity Testing Using OECD Test Guideline 488

Mutation Research / Genetic Toxicology and Environmental Mutagenesis, 2018

Marchetti F, Aardema MJ, Beevers C, van Benthem J, Douglas GR, ...

The Germ Cell Workgroup of the Genetic Toxicology (GTTC) Committee of the Health and Environmental Sciences Institute modeled mouse and rat spermatogenesis to better define the exposure history of the cell population collected from seminiferous tubules.

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Do Current Approaches to Assessing Therapy Related Adverse Events Align with the Needs of Long-Term Cancer Patients and Survivors?

Cardio-Oncology, 2018

Syril D. Pettit, Rebecca Kirch
  • HESI - Health and Environmental Sciences Institute

The increasing efficacy of cancer therapeutics means that the timespan of cancer therapy administration is undergoing a transition to increasingly long-term settings. Unfortunately, chronic therapy-related adverse health events are an unintended, but not infrequent, outcome of these life-saving therapies. ...

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