Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods

  • Publication Date :
  • Publication Type : Journal Article
  • Author(s) : Elespuru R, Pfuhler S, Aardema MJ, Chen T, Doak SH, Doherty A, Farabaugh CS, Kenny J, Manjanatha M, Mahadevan B, Moore MM, Ouédraogo G, Stankowski Jr. LF, & Tanir JY
  • Journal Name : Toxicological Sciences

Nanomaterials (NMs) present unique challenges in safety evaluation. An international working group, the Genetic Toxicology Technical Committee of the Health and Environmental Sciences Institute, has addressed issues related to the genotoxicity assessment of NMs. A critical review of published data has been followed by recommendations on methods alterations and best practices for the standard genotoxicity assays: bacterial reverse mutation (Ames); in vitro mammalian assays for mutations, chromosomal aberrations, micronucleus induction, or DNA strand breaks (comet); and in vivo assays for genetic damage (micronucleus, comet and transgenic mutation assays).

Full text online:

Contact Us

Health and Environmental Sciences Institute (HESI)
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.