Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Cytokine Release: A Workshop Proceedings on the State-of-the-Science, Current Challenges and Future Directions

Cytokine, 2016

Grimaldi C, Finco D, Fort MM, Gliddon D, Harper K, Helms WS, ...

In October 2013, the Health and Environmental Sciences Institute Immuno-Safety Technical Committee (ITC) held a one-day workshop entitled, “Workshop on Cytokine Release: State-of-the-Science, Current Challenges and Future Directions”. The workshop brought together scientists from pharmaceutical, academic, ...

Read more

Cytokine Release Assays: Current Practices and Future Directions

Cytokine, 2014

Finco D, Grimaldi C, Fort M, Walker M, Kiessling A, Wolf B, ...
  • HESI - Health and Environmental Sciences Institute

As a result of the CD28 superagonist biotherapeutic monoclonal antibody (TGN 1412) "cytokine storm" incident, cytokine release assays (CRA) have become hazard identification and prospective risk assessment tools for screening novel biotherapeutics directed against targets having a potential risk for eliciting ...

Read more

Current Practices in Preclinical Drug Development: Gaps in Hemostasis Testing to Assess Risk of Thromboembolic Injury

Toxicologic Pathology, 2013

Schultze AE, Walker DB, Turk JR, Tarrant JM, Brooks MB, Pettit SD
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute Cardiac Biomarkers Working Group surveyed the pharmaceutical development community to investigate practices in assessing hemostasis, including detection of hypocoagulable and hyper coagulable states.

Read more

Current Challenges in the Evaluation of Cardiac Safety During Drug Development: Translational Medicine Meets the Critical Path Initiative

American Heart Journal, 2009

Piccini JP, Whellan DJ, Berridge BR, Finkle JK, Pettit SD, ...
  • HESI - Health and Environmental Sciences Institute

In October 2008, in a public forum organized by the Cardiac Safety Research Consortium and the Health and Environmental Sciences Institute, leaders from government, the pharmaceutical industry, and academia convened in Bethesda, MD, to discuss current challenges in evaluation of short- and long-term cardiovascular safety ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 58
            [orderby] => title
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 58
            [orderby] => title
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_key] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [meta_table] => 
            [meta_id_column] => 
            [primary_table] => 
            [primary_id_column] => 
            [table_aliases:protected] => Array
                (
                )

            [clauses:protected] => Array
                (
                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts 
					WHERE 1=1  AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					
					ORDER BY wp_posts.post_title DESC
					LIMIT 342, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 22432
                    [post_author] => 2
                    [post_date] => 2020-03-23 12:09:52
                    [post_date_gmt] => 2020-03-23 17:09:52
                    [post_content] => 
                    [post_title] => Cytokine Release: A Workshop Proceedings on the State-of-the-Science, Current Challenges and Future Directions
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cytokine-release-a-workshop-proceedings-on-the-state-of-the-science-current-challenges-and-future-directions
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2020-10-28 15:03:14
                    [post_modified_gmt] => 2020-10-28 15:03:14
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=22432
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 2594
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:22:35
                    [post_date_gmt] => 2016-05-05 01:22:35
                    [post_content] => 
                    [post_title] => Cytokine Release Assays: Current Practices and Future Directions
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cytokine-release-assays-current-practices-and-future-directions
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:22:35
                    [post_modified_gmt] => 2016-05-05 01:22:35
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2594
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 3395
                    [post_author] => 6
                    [post_date] => 2016-06-26 22:35:24
                    [post_date_gmt] => 2016-06-27 03:35:24
                    [post_content] => 
                    [post_title] => Cytokine mRNA Profiles for Isocyanates With Known and Unknown Potential to Induce Respiratory Sensitization
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cytokine-mrna-profiles-for-isocyanates-with-known-and-unknown-potential-to-induce-respiratory-sensitization
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-26 22:35:24
                    [post_modified_gmt] => 2016-06-27 03:35:24
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3395
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 2690
                    [post_author] => 6
                    [post_date] => 2016-05-10 10:01:44
                    [post_date_gmt] => 2016-05-10 15:01:44
                    [post_content] => 
                    [post_title] => Current Practices in Preclinical Drug Development: Gaps in Hemostasis Testing to Assess Risk of Thromboembolic Injury
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => current-practices-in-preclinical-drug-development-gaps-in-hemostasis-testing-to-assess-risk-of-thromboembolic-injury
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-10 10:01:44
                    [post_modified_gmt] => 2016-05-10 15:01:44
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2690
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 3277
                    [post_author] => 6
                    [post_date] => 2016-06-20 22:43:23
                    [post_date_gmt] => 2016-06-21 03:43:23
                    [post_content] => 
                    [post_title] => Current Challenges in the Evaluation of Cardiac Safety During Drug Development: Translational Medicine Meets the Critical Path Initiative
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => current-challenges-in-the-evaluation-of-cardiac-safety-during-drug-development-translational-medicine-meets-the-critical-path-initiative
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-06-20 22:43:23
                    [post_modified_gmt] => 2016-06-21 03:43:23
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=3277
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 26519
                    [post_author] => 16
                    [post_date] => 2023-03-17 19:08:34
                    [post_date_gmt] => 2023-03-17 19:08:34
                    [post_content] => 
                    [post_title] => Current approaches to evaluate the function of cytotoxic T-cells in non-human primates
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => current-approaches-to-evaluate-the-function-of-cytotoxic-t-cells-in-non-human-primates
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2023-03-20 12:09:21
                    [post_modified_gmt] => 2023-03-20 12:09:21
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => https://hesiglobal.org/?post_type=publication&p=26519
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 22432
            [post_author] => 2
            [post_date] => 2020-03-23 12:09:52
            [post_date_gmt] => 2020-03-23 17:09:52
            [post_content] => 
            [post_title] => Cytokine Release: A Workshop Proceedings on the State-of-the-Science, Current Challenges and Future Directions
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => cytokine-release-a-workshop-proceedings-on-the-state-of-the-science-current-challenges-and-future-directions
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2020-10-28 15:03:14
            [post_modified_gmt] => 2020-10-28 15:03:14
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => https://hesiglobal.org/?post_type=publication&p=22432
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 479
    [max_num_pages] => 80
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => 56664d59ff399373fd5ff2bbe17feac1
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.