This book was published by ILSI Press, Washington, DC.
Pathogens and Disinfection By-Products in Drinking Water: Health Effects and Management of Risks
2001
Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.
2001
This book was published by ILSI Press, Washington, DC.
Regulatory Toxicology and Pharmacology, 2020
Physiologically-based pharmacokinetic (PBPK) modeling analysis does not stand on its own for regulatory purposes but is a robust tool to support drug/chemical safety assessment. While the development of PBPK models have grown steadily since their emergence, only a handful of models have been accepted to support regulatory ...
Environmental and Molecular Mutagenesis, 2021
A genotoxic carcinogen, N-nitrosodimethylamine (NDMA), was detected as a synthesis impurity in some valsartan drugs in 2018, and other N-nitrosamines, such as N-nitrosodiethylamine (NDEA), were later detected in other sartan products. N-nitrosamines are pro-mutagens that can react with DNA following metabolism to produce ...
Drug Metabolism and Disposition, 2019
This review is part of a multisector collaborative research effort coordinated by the HESI Developmental and Reproductive Toxicology (DART) Committee to increase the knowledge base in the nonclinical neonatal space to better inform clinical treatment decisions made for the newborn patient population (De Schaepdrijver et ...
Current Opinion in Toxicology, 2022
This short review paper, written by members of the Botanical Safety Consortium, explores botanical induced renal injuries and introduces new approach methodologies (NAMs) that could be used to identify the nephrotoxic potential of botanicals.
Environmental Health Perspectives, 2006
The use of biomonitoring data holds promise for characterizing exposure and informing risk assessment.
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