BMC Genomics, 2008
Boedigheimer MJ, Wolfinger RD, Bass MB, Bushel PR, Chou JW, ...
- HESI - Health and Environmental Sciences Institute
The use of gene expression profiling in both clinical and laboratory settings would be enhanced by better characterization of variance due to individual, environmental, and technical factors.
Clinical Chemistry, 2008
Apple FS, Murakami MM, Ler R, Walker D, York M, ...
- HESI - Health and Environmental Sciences Institute
Information is needed regarding analytical characteristics of cardiac troponin (cTn) assays used in preclinical studies.
British Journal of Pharmacology, 2008
Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, ...
- HESI - Health and Environmental Sciences Institute
Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients.
British Journal of Pharmacology, 2008
Bass AS, Darpo B, Valentin JP, Sager P, Thomas K
- HESI - Health and Environmental Sciences Institute
Drug-induced torsades de pointes (TdP) remains a significant public health concern that has challenged scientists who have the responsibility of advancing new medicines through development to the patient, while assuring public safety.
Environmental Toxicology and Chemistry, 2008
Arnot JA, Mackay D, Parkerton TF, Bonnell M
- HESI - Health and Environmental Sciences Institute
Biotransformation is a key process that can mitigate the bioaccumulation potential of organic substances and is an important parameter for exposure assessments.
Aquatic Toxicology, 2008
Han X, Mingoia RT, Nabb DL, Yang CH, Snajdr SI, Hoke RA
- HESI - Health and Environmental Sciences Institute
Metabolism plays an important role in bioaccumulation of xenobiotics in fish.
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