Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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HESI Cardiovascular Safety Subcommittee Initiative: Evaluation of Three Non-Clinical Models of QT Prolongation

Journal of Pharmacological and Toxicological Methods, 2006

Hanson LA, Bass AS, Gintant G, Mittelstadt S, Rampe D, Thomas K
  • HESI - Health and Environmental Sciences Institute

Drugs that delay cardiac repolarization pose potential safety risks to patients and cause serious regulatory concern because of the link between QT interval prolongation and the potentially fatal arrhythmia torsades de pointes (TdP).

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Hemangiosarcoma in Rodents: Mode-of-Action Evaluation and Human Relevance

Toxicological Sciences, 2009

Cohen SM, Storer RD, Criswell KA, Doerrer NG, Dellarco VL, ...
  • HESI - Health and Environmental Sciences Institute

Although rarely occurring in humans, hemangiosarcomas (HS) have become important in evaluating the potential human risk of several chemicals, including industrial, agricultural, and pharmaceutical agents.

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Health Disparities, COVID-19, and Owning Our Share

Toxicological Sciences, 2020

Pettit SD

The COVID-19 pandemic has left many frightened, saddened, and angered at its impact on our lives and the world around us. The disease has laid bare failures to protect our citizens generally but our vulnerable and underserved most of all. Growing evidence reveals that minority and low-income populations are experiencing ...

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Health and Environmental Sciences Institute (HESI) Initiative on Moving Towards Better Predictors of Drug‐Induced Torsades de Pointes

British Journal of Pharmacology, 2008

Bass AS, Darpo B, Breidenbach A, Bruse K, Feldman HS, Garnes D, ...
  • HESI - Health and Environmental Sciences Institute

Knowledge of the cardiac safety of emerging new drugs is an important aspect of assuring the expeditious advancement of the best candidates targeted at unmet medical needs while also assuring the safety of clinical trial subjects or patients.

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Health and Environmental Sciences Institute (HESI)

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