In a repeat oral dose toxicity study, all of 16 male rats given 100 mg/kg/day GSK1322888 sustained testicular injury after 4 weeks of treatment; the findings were not reversible after 12 weeks off-dose.
The Inhibin B Response to a Motilin Receptor Agonist in Male Rats
Birth Defects Research Part B: Developmental and Reproductive Toxicology, 2013