Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
Filter

Rechanneling the Cardiac Proarrhythmia Safety Paradigm: A Meeting Report From the Cardiac Safety Research Consortium

American Heart Journal, 2014

Sager PT, Gintant G, Turner JR, Pettit S, Stockbridge N
  • HESI - Health and Environmental Sciences Institute

This white paper provides a summary of a scientific proposal presented at a Cardiac Safety Research Consortium/Health and Environmental Sciences Institute/Food and Drug Administration–sponsored Think Tank, held at Food and Drug Administration's White Oak facilities, Silver Spring, MD, on July 23, 2013, with the intention ...

Read more

Normal Ranges and Variability of Novel Urinary Renal Biomarkers in Sprague-Dawley Rats: Comparison of Constitutive Values Between Males and Females and Across Assay Platforms

Toxicologic Pathology, 2014

Gautier JC, Gury T, Guffroy M, Khan-Malek R, Hoffman D, Pettit S, ...
  • HESI - Health and Environmental Sciences Institute

Differences were examined between male and female Sprague-Dawley rats in basal levels of a wide range of urinary biomarkers, including 7 recently qualified biomarkers.

Read more

Cytokine Release Assays: Current Practices and Future Directions

Cytokine, 2014

Finco D, Grimaldi C, Fort M, Walker M, Kiessling A, Wolf B, ...
  • HESI - Health and Environmental Sciences Institute

As a result of the CD28 superagonist biotherapeutic monoclonal antibody (TGN 1412) "cytokine storm" incident, cytokine release assays (CRA) have become hazard identification and prospective risk assessment tools for screening novel biotherapeutics directed against targets having a potential risk for eliciting ...

Read more

WP_Query Object
(
    [query] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 35
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
        )

    [query_vars] => Array
        (
            [post_type] => publication
            [posts_per_page] => 6
            [type] => 
            [area] => 
            [committee] => 
            [authors] => true
            [showtitle] => false
            [meta_query] => Array
                (
                    [relation] => AND
                )

            [tax_query] => Array
                (
                )

            [paged] => 35
            [meta_key] => _ilsi_date
            [orderby] => meta_value
            [order] => DESC
            [error] => 
            [m] => 
            [p] => 0
            [post_parent] => 
            [subpost] => 
            [subpost_id] => 
            [attachment] => 
            [attachment_id] => 0
            [name] => 
            [pagename] => 
            [page_id] => 0
            [second] => 
            [minute] => 
            [hour] => 
            [day] => 0
            [monthnum] => 0
            [year] => 0
            [w] => 0
            [category_name] => 
            [tag] => 
            [cat] => 
            [tag_id] => 
            [author] => 
            [author_name] => 
            [feed] => 
            [tb] => 
            [meta_value] => 
            [preview] => 
            [s] => 
            [sentence] => 
            [title] => 
            [fields] => 
            [menu_order] => 
            [embed] => 
            [category__in] => Array
                (
                )

            [category__not_in] => Array
                (
                )

            [category__and] => Array
                (
                )

            [post__in] => Array
                (
                )

            [post__not_in] => Array
                (
                )

            [post_name__in] => Array
                (
                )

            [tag__in] => Array
                (
                )

            [tag__not_in] => Array
                (
                )

            [tag__and] => Array
                (
                )

            [tag_slug__in] => Array
                (
                )

            [tag_slug__and] => Array
                (
                )

            [post_parent__in] => Array
                (
                )

            [post_parent__not_in] => Array
                (
                )

            [author__in] => Array
                (
                )

            [author__not_in] => Array
                (
                )

            [search_columns] => Array
                (
                )

            [ignore_sticky_posts] => 
            [suppress_filters] => 
            [cache_results] => 1
            [update_post_term_cache] => 1
            [update_menu_item_cache] => 
            [lazy_load_term_meta] => 1
            [update_post_meta_cache] => 1
            [nopaging] => 
            [comments_per_page] => 50
            [no_found_rows] => 
        )

    [tax_query] => WP_Tax_Query Object
        (
            [queries] => Array
                (
                )

            [relation] => AND
            [table_aliases:protected] => Array
                (
                )

            [queried_terms] => Array
                (
                )

            [primary_table] => wp_posts
            [primary_id_column] => ID
        )

    [meta_query] => WP_Meta_Query Object
        (
            [queries] => Array
                (
                    [0] => Array
                        (
                            [key] => _ilsi_date
                        )

                    [relation] => OR
                )

            [relation] => AND
            [meta_table] => wp_postmeta
            [meta_id_column] => post_id
            [primary_table] => wp_posts
            [primary_id_column] => ID
            [table_aliases:protected] => Array
                (
                    [0] => wp_postmeta
                )

            [clauses:protected] => Array
                (
                    [wp_postmeta] => Array
                        (
                            [key] => _ilsi_date
                            [compare] => =
                            [compare_key] => =
                            [alias] => wp_postmeta
                            [cast] => CHAR
                        )

                )

            [has_or_relation:protected] => 
        )

    [date_query] => 
    [request] => 
					SELECT SQL_CALC_FOUND_ROWS  wp_posts.ID
					FROM wp_posts  INNER JOIN wp_postmeta ON ( wp_posts.ID = wp_postmeta.post_id )
					WHERE 1=1  AND ( 
  wp_postmeta.meta_key = '_ilsi_date'
) AND ((wp_posts.post_type = 'publication' AND (wp_posts.post_status = 'publish' OR wp_posts.post_status = 'acf-disabled')))
					GROUP BY wp_posts.ID
					ORDER BY wp_postmeta.meta_value DESC
					LIMIT 204, 6
				
    [posts] => Array
        (
            [0] => WP_Post Object
                (
                    [ID] => 2624
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:18:21
                    [post_date_gmt] => 2016-05-05 01:18:21
                    [post_content] => 
                    [post_title] => Rechanneling the Cardiac Proarrhythmia Safety Paradigm: A Meeting Report From the Cardiac Safety Research Consortium
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => rechanneling-the-cardiac-proarrhythmia-safety-paradigm-a-meeting-report-from-the-cardiac-safety-research-consortium
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:18:21
                    [post_modified_gmt] => 2016-05-05 01:18:21
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2624
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [1] => WP_Post Object
                (
                    [ID] => 2600
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:22:29
                    [post_date_gmt] => 2016-05-05 01:22:29
                    [post_content] => 
                    [post_title] => Normal Ranges and Variability of Novel Urinary Renal Biomarkers in Sprague-Dawley Rats: Comparison of Constitutive Values Between Males and Females and Across Assay Platforms
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => normal-ranges-and-variability-of-novel-urinary-renal-biomarkers-in-sprague-dawley-rats-comparison-of-constitutive-values-between-males-and-females-and-across-assay-platforms
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:22:29
                    [post_modified_gmt] => 2016-05-05 01:22:29
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2600
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [2] => WP_Post Object
                (
                    [ID] => 2606
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:22:15
                    [post_date_gmt] => 2016-05-05 01:22:15
                    [post_content] => 
                    [post_title] => Quantitative Mapping of Trimethyltin Injury in the Rat Brain Using Magnetic Resonance Histology
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => quantitative-mapping-of-trimethyltin-injury-in-the-rat-brain-using-magnetic-resonance-histology
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:22:15
                    [post_modified_gmt] => 2016-05-05 01:22:15
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2606
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [3] => WP_Post Object
                (
                    [ID] => 2580
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:24:06
                    [post_date_gmt] => 2016-05-05 01:24:06
                    [post_content] => 
                    [post_title] => Approaches and Considerations for the Assessment of Immunotoxicity for Environmental Chemicals: A Workshop Summary
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => approaches-and-considerations-for-the-assessment-of-immunotoxicity-for-environmental-chemicals-a-workshop-summary
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:24:06
                    [post_modified_gmt] => 2016-05-05 01:24:06
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2580
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [4] => WP_Post Object
                (
                    [ID] => 2621
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:19:49
                    [post_date_gmt] => 2016-05-05 01:19:49
                    [post_content] => 
                    [post_title] => From Silos to Multilingual Science
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => from-silos-to-multilingual-science
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:19:49
                    [post_modified_gmt] => 2016-05-05 01:19:49
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2621
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

            [5] => WP_Post Object
                (
                    [ID] => 2594
                    [post_author] => 6
                    [post_date] => 2016-05-04 20:22:35
                    [post_date_gmt] => 2016-05-05 01:22:35
                    [post_content] => 
                    [post_title] => Cytokine Release Assays: Current Practices and Future Directions
                    [post_excerpt] => 
                    [post_status] => publish
                    [comment_status] => closed
                    [ping_status] => closed
                    [post_password] => 
                    [post_name] => cytokine-release-assays-current-practices-and-future-directions
                    [to_ping] => 
                    [pinged] => 
                    [post_modified] => 2016-05-04 20:22:35
                    [post_modified_gmt] => 2016-05-05 01:22:35
                    [post_content_filtered] => 
                    [post_parent] => 0
                    [guid] => http://ilsi.org/hesi/?post_type=publication&p=2594
                    [menu_order] => 0
                    [post_type] => publication
                    [post_mime_type] => 
                    [comment_count] => 0
                    [filter] => raw
                )

        )

    [post_count] => 6
    [current_post] => -1
    [before_loop] => 
    [in_the_loop] => 
    [post] => WP_Post Object
        (
            [ID] => 2624
            [post_author] => 6
            [post_date] => 2016-05-04 20:18:21
            [post_date_gmt] => 2016-05-05 01:18:21
            [post_content] => 
            [post_title] => Rechanneling the Cardiac Proarrhythmia Safety Paradigm: A Meeting Report From the Cardiac Safety Research Consortium
            [post_excerpt] => 
            [post_status] => publish
            [comment_status] => closed
            [ping_status] => closed
            [post_password] => 
            [post_name] => rechanneling-the-cardiac-proarrhythmia-safety-paradigm-a-meeting-report-from-the-cardiac-safety-research-consortium
            [to_ping] => 
            [pinged] => 
            [post_modified] => 2016-05-04 20:18:21
            [post_modified_gmt] => 2016-05-05 01:18:21
            [post_content_filtered] => 
            [post_parent] => 0
            [guid] => http://ilsi.org/hesi/?post_type=publication&p=2624
            [menu_order] => 0
            [post_type] => publication
            [post_mime_type] => 
            [comment_count] => 0
            [filter] => raw
        )

    [comment_count] => 0
    [current_comment] => -1
    [found_posts] => 479
    [max_num_pages] => 80
    [max_num_comment_pages] => 0
    [is_single] => 
    [is_preview] => 
    [is_page] => 
    [is_archive] => 
    [is_date] => 
    [is_year] => 
    [is_month] => 
    [is_day] => 
    [is_time] => 
    [is_author] => 
    [is_category] => 
    [is_tag] => 
    [is_tax] => 
    [is_search] => 
    [is_feed] => 
    [is_comment_feed] => 
    [is_trackback] => 
    [is_home] => 1
    [is_privacy_policy] => 
    [is_404] => 
    [is_embed] => 
    [is_paged] => 1
    [is_admin] => 
    [is_attachment] => 
    [is_singular] => 
    [is_robots] => 
    [is_favicon] => 
    [is_posts_page] => 
    [is_post_type_archive] => 
    [query_vars_hash:WP_Query:private] => ae5bf329473bcd86b5bc463906905deb
    [query_vars_changed:WP_Query:private] => 
    [thumbnails_cached] => 
    [allow_query_attachment_by_filename:protected] => 
    [stopwords:WP_Query:private] => 
    [compat_fields:WP_Query:private] => Array
        (
            [0] => query_vars_hash
            [1] => query_vars_changed
        )

    [compat_methods:WP_Query:private] => Array
        (
            [0] => init_query_flags
            [1] => parse_tax_query
        )

)

Contact Us

Health and Environmental Sciences Institute (HESI)

hesi@hesiglobal.org
Phone: +1-202-659-8404
Fax: +1-202-659-3859

740 15th Street NW, Suite 600
Washington, DC 20005

Stay Informed

Sign up for our monthly e-newsletter.