Peer-Reviewed
Publications

Open access, peer-reviewed publications ensure that knowledge is a public good. HESI believes that accessible research is critical for equitable engagement, diverse collaboration, and increased interdisciplinary conversation. We strive to achieve open access on all publications, and more than 200 publications from HESI programs have been published in the last decade.

Impact of HESI Publications
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Need and Potential Value of the Pig‐a In Vivo Mutation Assay—A HESI Perspective

Environmental and Molecular Mutagenesis, 2011

Schuler M, Gollapudi BB, Thybaud V, Kim JH
  • HESI - Health and Environmental Sciences Institute

The Health and Environmental Sciences Institute (HESI), a global branch of the International Life Sciences Institute (ILSI), initiated a project committee entitled “Relevance and Follow-up of Positive Results from In Vitro Genetic Toxicity Testing (IVGT)” with the overall objective of improving the scientific basis for ...

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Mutagenesis Special Issue: Quantitative Genetic Toxicology (2016) This special issue was inspired by the HESI Genetic Toxicology Technical Committee’s Workshop: Genetic Toxicology at the Crossroads – From Qualitative Hazard Evaluation to Quantitative Risk Assessment

Mutagenesis, 2016

Multiple Contributors
  • HESI - Health and Environmental Sciences Institute

Applied genetic toxicology is undergoing a transition from qualitative hazard identification to quantitative dose–response analysis and risk assessment. To facilitate this change, the Health and Environmental Sciences Institute (HESI) Genetic Toxicology Technical Committee (GTTC) sponsored a workshop held in ...

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Moving Towards Better Predictors of Drug‐Induced Torsades de Pointes

British Journal of Pharmacology, 2008

Bass AS, Darpo B, Valentin JP, Sager P, Thomas K
  • HESI - Health and Environmental Sciences Institute

Drug-induced torsades de pointes (TdP) remains a significant public health concern that has challenged scientists who have the responsibility of advancing new medicines through development to the patient, while assuring public safety.

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Mode of Action in Relevance of Rodent Liver Tumors to Human Cancer Risk

Toxicological Sciences, 2006

Holsapple MP, Pitot HC, Cohen SH, Boobis AR, Klaunig JE, ...
  • HESI - Health and Environmental Sciences Institute

Hazard identification and risk assessment paradigms depend on the presumption of the similarity of rodents to humans, yet species specific responses, and the extrapolation of high-dose effects to low-dose exposures can affect the estimation of human risk from rodent data.

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